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Assessment of factors associated with antipsychotic-induced weight gain: A nationwide cohort study.
Prog Neuropsychopharmacol Biol Psychiatry
December 2024
Department of Psychiatry, Hokkaido University Graduate School of Medicine, Sapporo 060-8638, Japan. Electronic address:
Background: The incidence of antipsychotic-induced weight gain (AIWG) is difficult to predict in real-world practice because various factors influence it. This study aimed to explore background and medication-related factors associated with weight gain in patients newly prescribed with antipsychotic medication.
Methods: This nationwide, multicenter, prospective cohort study was conducted in Japan.
Identification of serum metabolic traits of AIWG in first-episode schizophrenia patients.
BMC Psychiatry
December 2024
Division of Psychotic Disorders, Shanghai Mental Health Center, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Background: Antipsychotic-induced weight gain (AIWG) is a common side effect of antipsychotic drugs and may lead to cardiometabolic comorbidities. There is an urgent public health need to identify patients at high risk of AIWG and determine potential biomarkers for AIWG.
Methods: In the Sequential Multiple-Assignment Randomized Trials to Compare Antipsychotic Treatments (SMART-CAT) trail, first-episode schizophrenia patients were randomly assigned to olanzapine, risperidone, perphenazine, amisulpride or aripiprazole for 8 weeks.
Author's Response to Letter to the Editor Concerning "Glucagon-Like Peptide Agonists for Weight Management in Antipsychotic-Induced Weight Gain: A Systematic Review and Meta-Analysis" by Anders Fink-Jensen|Christoph U. Correll.
Acta Psychiatr Scand
December 2024
Department of Psychiatry & Neuropsychology, Maastricht University, Maastricht, The Netherlands.
Exploring the effects of probiotics on olanzapine-induced metabolic syndrome through the gut microbiota.
Gut Pathog
December 2024
Department of Pharmacology, Kasturba Medical College, Manipal, Manipal Academy of Higher Education, Manipal, Karnataka, 576104, India.
Background: Maintaining gut microbial homeostasis is crucial for human health, as imbalances in the gut microbiota (GM) can lead to various diseases, including metabolic syndrome (MS), exacerbated by the use of antipsychotic medications such as olanzapine (OLZ). Understanding the role of the GM in OLZ-induced MS could lead to new therapeutic strategies. This study used metagenomic analysis to explore the impact of OLZ on the GM composition and examined how probiotics can mitigate its adverse effects in a rat model.
View Article and Find Full Text PDFMetformin for the Prevention of Antipsychotic-Induced Weight Gain: Guideline Development and Consensus Validation.
Schizophr Bull
December 2024
School of Medicine, University College Dublin, Dublin, D04 V1W8, Ireland.
Background: Overweight and obesity are highly prevalent in people with severe mental illness (SMI). Antipsychotic-induced weight gain (AIWG) is one of the most commonly reported and distressing side effects of treatment and people living with SMI place a high value on the avoidance of this side effect. Metformin is the most effective pharmacological intervention studied for the prevention of AIWG yet clear guidelines are lacking and evidence has not translated into practice.
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