The synthesis and kinase inhibitory activity of a series of novel 1,7-annulated indolocarbazoles 6 and 16 is described. These compounds exhibited potent inhibitory activity against cyclin-dependent kinase 4 and good antiproliferative activity in a human colon carcinoma cell line.
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http://dx.doi.org/10.1016/j.bmcl.2004.03.105 | DOI Listing |
Pharmaceuticals (Basel)
December 2024
Laboratory of Molecular and Cellular Neurogenetics, N.N. Burdenko National Medical Research Center of Neurosurgery, 125047 Moscow, Russia.
Indolo[2,3-]pyrrolo[3,4-]carbazole scaffold is successfully used as an efficient structural motif for the design and development of different antitumor agents. In this study, we investigated the anti-glioblastoma therapeutic potential of glycosylated indolocarbazole analog LCS1269 utilizing in vitro, in vivo, and in silico approaches. Cell viability was estimated by an MTT assay.
View Article and Find Full Text PDFSpectrochim Acta A Mol Biomol Spectrosc
December 2024
School of Chemistry and Chemical Engineering, Guizhou University, Guiyang 550025, PR China. Electronic address:
Detections towards multiple analytes by one sensor remain a significant challenges. Herein, a high-sensitivity chemo-sensor ICZ-o-XFJ is designed and synthesized for the simultaneous detection of F and Al. Suffering from the ESIPT process, this sensor is colorless and almost non-emissive in solutions.
View Article and Find Full Text PDFChem Commun (Camb)
November 2024
Department of Chemistry, Yonsei University, Seoul 03722, Republic of Korea.
A series of pyridinium-indolocarbazole oligomers with different lengths, capable of adopting helical conformations with tubular cavities, has been synthesized. These oligomers can accommodate two, three, or four iodide ions in a linear arrangement within their cavities, which can be exchanged with other halides.
View Article and Find Full Text PDFNat Commun
November 2024
Department of Physics, Durham University, South Road, Durham, DH1 3LE, UK.
Intramolecular charge transfer (ICT) occurs when photoexcitation causes electron transfer from an electron donor to an electron acceptor within the same molecule and is usually stabilized by decoupling of the donor and acceptor through an orthogonal twist between them. Thermally activated delayed fluorescence (TADF) exploits such twisted ICT states to harvest triplet excitons in OLEDs. However, the highly twisted conformation of TADF molecules results in limited device lifetimes.
View Article and Find Full Text PDFAngew Chem Int Ed Engl
January 2025
Université Paris-Saclay, CEA, INRAE, Département Médicaments et Technologies pour la Santé (DMTS), SCBM, Gif-sur-Yvette, F-91191, France.
Recently, the control of dynamic chirality has emerged as a powerful strategy to design chiral functional materials. In this context, we describe herein a molecular design in which a tethered configurationally stable binaphthyl chiral unit efficiently controls the dynamic chirality of donor-acceptor fluorophores, involving diverse indolocarbazoles as electron donors and terephthalonitrile as an electron acceptor. The high conformational discrimination in such a molecular system suggested by density functional theory calculations is experimentally probed using electronic and vibrational circular dichroism and confirmed by the crystallization of these chiral molecules in gel and their single crystal X-ray diffraction analysis.
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