A 49-year-old man with penile cancer (cT3N1M0) was referred to our hospital. The pathologic diagnosis was squamous cell carcinoma. The patient underwent penectomy and bilateral inguinal lymphadenectomy without postoperative adjuvant therapy. Six months later, we found multiple metastases of the penile cancer in the lungs. The patient was then treated with combination chemotherapy of cisplatin, methotrexate, bleomycin. However, the tumors were aggressive and did not respond to the therapy. We discuss the use of combination chemotherapy in the case of advanced penile cancer.

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