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http://dx.doi.org/10.1159/000078436 | DOI Listing |
J Neurosci
May 2019
Departments of Ophthalmology,
Peripherin 2 (PRPH2) is a tetraspanin protein concentrated in the light-sensing cilium (called the outer segment) of the vertebrate photoreceptor. The mechanism underlying the ciliary targeting of PRPH2 and the etiology of cone dystrophy caused by PRPH2 mutations remain elusive. Here we show that the late endosome (LE) is the main waystation that critically sorts newly synthesized PRPH2 to the cilium.
View Article and Find Full Text PDFPancreatology
December 2004
Universitätsklinikum Leipzig, Medizinische Klinik und Poliklinik II, Leipzig, Germany.
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