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Pheochromocytoma crisis precipitated by dexamethasone with profound lactic acidosis, but without severe hypertension.
Endocrinol Diabetes Metab Case Rep
November 2022
Department of Anesthesiology, Perioperative, and Pain Medicine, Stanford University School of Medicine, Stanford, CA, USA.
Summary: We describe a case of a 47-year-old patient who presented with severe lactic acidosis, troponinemia, and acute kidney injury after receiving 8 mg of intramuscular dexamethasone for seasonal allergies in the setting of an undiagnosed epinephrine-secreting pheochromocytoma. This case was atypical, however, in that the patient exhibited only mildly elevated noninvasive measured blood pressures. Following a period of alpha-adrenergic blockade, the tumor was resected successfully.
View Article and Find Full Text PDFMetastatic pheochromocytoma and paraganglioma (PPGL) have poor prognosis and limited therapeutic options. The recent advent of immunotherapies showing remarkable clinical efficacies against various cancer types offers the possibility of novel opportunities also for metastatic PPGL. Most PPGLs are pathogenically linked to inactivating mutations in genes encoding different succinate dehydrogenase (SDH) subunits.
View Article and Find Full Text PDFReverse takotsubo cardiomyopathy- life-threatening symptom of an incidental pheochromocytoma: a case report.
Eur Heart J Case Rep
December 2019
Technische Universität Dresden, Department of Internal Medicine and Cardiology, Herzzentrum Dresden, University Clinic, Fetscherstraße 76, 01307 Dresden, Germany.
Background: Cardiogenic shock (CS) due to takotsubo cardiomyopathy (TTC) is a life-threatening condition. Therapy is challenging because of the ambivalent effects of catecholamines. Catecholamines are required to stabilize blood pressure but might aggravate TTC.
View Article and Find Full Text PDFLocal recurrence of pheochromocytoma in multiple endocrine neoplasia type 2A: a diagnostic and therapeutic challenge.
Clin Case Rep
March 2016
Service d'Endocrinologie et Maladies Métaboliques Pôle Cardio-Vasculaire et Métabolique CHU Larrey Toulouse France.
In a patient with multiple endocrine neoplasia type 2A (MEN2A), an inverted physiological ratio between urinary normetanephrines and metanephrines is an early marker of recurrence in epinephrine-secreting pheochromocytoma, and 131I MIBG treatment appears to be a useful therapeutic option in order to avoid multiple invasive surgical procedures in pheochromocytomatosis.
View Article and Find Full Text PDFEpinephrine-secreting large incidental pheochromocytoma in a normotensive male with stormy intraoperative hemodynamics.
Gulf J Oncolog
May 2015
Department of Anaesthesiology, Artemis Health Institute, Sec-51 Gurgaon Haryana, India.
Pheochromocytoma is a rare tumour which is usually suggested by sustained or paroxysmal hypertension however the spectrum of the presentation of pheochromocytoma continues to expand and hypertension may be absent despite excess catecholamine secretion. The normotensive pheochromocytoma is a distinct entity and as in the case we report the presentation was quite unique as well as the intraoperative behaviour was stormy.
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