[Therapeutic targets in diabetic vasculopathy].

Vascular complications are the main cause of morbidity and mortality in long-term diabetes mellitus. Endothelial dysfunction appears as an initial pathological mechanism leading to diabetic vasculopathy, which is associated with sustained high glucose levels and enhanced oxidative stress. Non-enzymatic protein glycosylation, through the formation of so-called advanced glycosylation end-products, appears as one of the mechanisms involved in diabetes-associated endothelial dysfunction. Our research group further proposes that early and intermediate glycosylation products (Amadori products), which are able to release reactive oxygen species, can also play a relevant role in the development of diabetic vasculopathy.