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Medical Management of the Near-Narrowed Internal Auditory Canal Pathology in the Adult Population: A Preliminary Study.
J Clin Med
January 2025
Department of Audiology and Otoneurological Explorations, Civil Hospitals of Lyon, 69003 Lyon, France.
: Objective: To discuss therapeutic outcomes in patients with symptomatic near-narrow internal auditory canal (NNIAC). : We retrospectively analyzed the records of 26 symptomatic patients diagnosed with NNIAC, who had been treated with anti-epileptic drugs. In addition to clinical and radiological data, we recorded I-III latencies of auditory brainstem responses prior to and after medical therapy.
View Article and Find Full Text PDFLate-Onset Idiopathic Generalized Epilepsy Manifesting With De Novo Late-Onset Absence Status Epilepticus After COVID-19 Infection: A Case Report.
Cureus
November 2024
Department of Epileptology, National Center Hospital, National Center of Neurology and Psychiatry, Tokyo, JPN.
Herein, we present a case of idiopathic generalized epilepsy (IGE) manifesting as de novo late-onset absence status epilepticus (ASE) following mild coronavirus disease 2019 (COVID-19). A woman in her 40s presented with persistent 3-5.5 Hz generalized spike-wave complexes (SWCs) on electroencephalography (EEG).
View Article and Find Full Text PDFA Case of BRASH Syndrome Required Two Hospitalizations in a Short Period.
Cureus
October 2024
Emergency Medicine, Kanto Central Hospital, Setagaya-Ku, JPN.
BRASH syndrome, characterized by bradycardia, renal failure, atrioventricular (AV) nodal blockade, shock, and hyperkalemia, is a recently identified syndrome typically caused by the interplay of electrolyte imbalances and medications such as beta-blockers and calcium channel blockers. This report presents the case of a 79-year-old woman with a history of epilepsy and hypertension, managed with carbamazepine, lamotrigine, and antihypertensive medications. She developed BRASH syndrome following reduced fluid intake and worsening renal function.
View Article and Find Full Text PDFAntiseizure medication use during pregnancy and children's neurodevelopmental outcomes.
Nat Commun
November 2024
A.J. Drexel Autism Institute, Drexel University, Philadelphia, PA, USA.
The teratogenic potential of valproate in pregnancy is well established; however, evidence regarding the long-term safety of other antiseizure medications (ASMs) during pregnancy remains limited. Using routinely collected primary care data from the UK and nationwide Swedish registries to create a cohort of 3,182,773 children, of which 17,495 were exposed to ASMs in pregnancy, we show that those exposed to valproate were more likely to receive a diagnosis of autism, intellectual disability, and ADHD, when compared to children not exposed to ASMs. Additionally, children exposed to topiramate were 2.
View Article and Find Full Text PDFEffects of frequently prescribed antiseizure medications on motor vehicle driving performance: Narrative review based on a tiered approach for the assessment of clinically meaningful driving impairment in the Ministry of Health, Labour, and Welfare guideline.
Neuropsychopharmacol Rep
December 2024
Pathophysiology of Mental Disorders, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Patients with epilepsy often require long-term treatment with antiseizure medications, and their impact on daily activities, particularly driving, is of significant concern. The recently published "Guideline for Evaluating Effects of Psychotropic Drugs on the Performance to Drive a Motor Vehicle" in Japan provides a framework that can be referred to for not only the evaluation of new drugs but also the reevaluation of approved drugs. This study conducted a literature review regarding the effects of carbamazepine, valproate, lamotrigine, lacosamide, and levetiracetam, which are frequently prescribed for epilepsy, on driving performance following the guideline's tiered evaluation approach.
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