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This extensive AWMF 085-002 S2e-guideline "First Trimester Diagnosis and Therapy @ 11 - 13 of Gestation" has systematically analyzed high-quality studies and publications and the existing evidence (evidence tables) and produced recommendations (level of recommendation, level of evidence, strength of consensus). This guideline deals with the following topics in the context of the 11 - 13 weeks scan: the legal basis, screening for anatomical malformations, screening for chromosomal defects, quality assessment and audit, screening for preeclampsia and FGR, screening for preterm birth, screening for abnormally invasive placenta (AIP) and placenta accreta spectrum (PAS), screening for velamentous cord insertion and vasa praevia, screening for diabetes mellitus and LGA. Screening for complications of pregnancy can best be carried out @ 11 - 13 weeks of gestation.

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Article Synopsis
  • The AWMF 085-002 S2e-guideline provides detailed recommendations based on high-quality studies for screening and managing pregnancy complications during the 11-13 weeks of gestation scan.
  • Key topics include screening for anatomical malformations, chromosomal defects, preeclampsia, and other conditions, with solutions for identifying many issues already in place.
  • While some complications can be effectively screened and managed in early pregnancy, challenges remain in identifying disorders related to glucose metabolism and preterm birth, making early detection crucial for better outcomes in pregnancy management.
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Article Synopsis
  • - The AWMF 085-002 S2e-guideline provides detailed recommendations based on high-quality studies for screening and diagnosing various pregnancy-related issues between 11-13 weeks of gestation, including anatomical malformations and chromosomal defects.
  • - It emphasizes the importance of first-trimester screening for complications such as preeclampsia, abnormal placentation, and growth retardation, noting that some identification methods are effective while others, like glucose metabolism disorders, remain insufficient.
  • - The guideline also highlights that early diagnosis allows for better management of pregnancy complications, including the option for lower-risk terminations if needed, and reassures parents through appropriate follow-ups, reducing unnecessary examinations.
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Article Synopsis
  • The AWMF 085-002 S2e-guideline provides evidence-based recommendations for diagnosing and managing various pregnancy complications during the critical 11-13 week scan.
  • It covers topics such as screening for anatomical malformations, chromosomal defects, preeclampsia, and other significant conditions, providing clarity on how to identify these issues.
  • While many screening challenges have been addressed, some like glucose metabolism disorders and preterm birth remain unresolved, emphasizing the importance of early screening for better pregnancy management.
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To explore whether digital finance can reduce agricultural carbon emissions, promote regional convergence, and foster inclusivity in rural revitalization and shared prosperity, this paper uses the provincial-level index of digital financial inclusion to analyze the impact of digital financial inclusion on the intensity of agricultural carbon emissions and the Degum Gini coefficient (D-Gini coefficient) of regional carbon emission intensity in 30 sample provinces from 2010 to 2020. It examines the mechanism of the impact of digital financial inclusion on both variables to understand the underlying factors better. The main conclusions are as follows: (1) Digital financial inclusion significantly reduces the intensity of agricultural carbon emissions and narrows the gap in carbon emission intensity between regions.

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