AI Article Synopsis
- In a study with mononeuropathic rats, repeated injections of 10 mg/kg venlafaxine led to a significant decrease in spinal wind-up responses, while 2.5 mg/kg did not show this effect.
- The findings suggest that venlafaxine, which inhibits serotonin reuptake, effectively reduces pain-related responses in these rats.
- Additionally, using the 5-HT1A receptor antagonist WAY 100,635 alongside venlafaxine enhanced its pain-reducing effects, indicating a potential pathway for improving treatment outcomes.
Article Abstract
In mononeuropathic rats submitted to a C-fiber reflex responses paradigm, repeated administration (five successive injections every half-life) of 10 mg/kg, s.c. of venlafaxine, but not of 2.5 mg/kg, s.c., a mixed monoamine reuptake inhibitor with preferential inhibitory activity in 5-HT reuptake, induced a progressive reduction of spinal wind-up. Repeated co-administration of the selective 5-HT1A receptor antagonist WAY 100,635 i.c.v. (50 microg/injection) significantly increased the effect of venlafaxine s.c., indicating that venlafaxine-induced inhibition of spinal wind-up in mononeuropathic rats is potentiated by blockade of central 5-HT1A receptors.
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| http://dx.doi.org/10.1016/j.brainres.2004.02.041 | DOI Listing |
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