This paper describes a data mining environment for knowledge discovery in bioinformatics applications. The system has a generic kernel that implements the mining functions to be applied to input primary databases, with a warehouse architecture, of biomedical information. Both supervised and unsupervised classification can be implemented within the kernel and applied to data extracted from the primary database, with the results being suitably stored in a complex object database for knowledge discovery. The kernel also includes a specific high-performance library that allows designing and applying the mining functions in parallel machines. The experimental results obtained by the application of the kernel functions are reported.
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http://dx.doi.org/10.1016/S0010-4825(03)00073-8 | DOI Listing |
J Surg Res
December 2024
Division of Pediatric Surgery, Department of Surgery, Washington University School of Medicine, Saint Louis, Missouri. Electronic address:
The mammalian intestine is a highly organized and complex system essential for nutrient absorption, immune response, and homeostasis. Disruptions in its development can lead to various gut diseases, ranging from congenital anomalies to inflammatory and neoplastic disorders. Caenorhabditis elegans (C elegans) has emerged as a valuable model organism for studying intestinal development and gut diseases due to its genetic tractability and transparent body.
View Article and Find Full Text PDFTrends Biochem Sci
December 2024
Walter and Eliza Hall Institute of Medical Research, 1G Royal Parade, Parkville, VIC 3052, Australia; Department of Medical Biology, University of Melbourne, Parkville, VIC 3052, Australia; Drug Discovery Biology, Monash Institute of Pharmaceutical Sciences, Monash University, Parkville, VIC 3052, Australia. Electronic address:
Necroptosis is a mode of programmed cell death executed by the mixed lineage kinase domain-like (MLKL) pseudokinase following its activation by the upstream receptor-interacting protein kinase-3 (RIPK3), subsequent to activation of death, Toll-like, and pathogen receptors. The pathway originates in innate immunity, although interest has surged in therapeutically targeting necroptosis owing to its dysregulation in inflammatory diseases. Here, we explore how protein conformation and higher order assembly of the pathway effectors - Z-DNA-binding protein-1 (ZBP1), RIPK1, RIPK3, and MLKL - can be modulated by post-translational modifications, such as phosphorylation, ubiquitylation, and lipidation, and intermolecular interactions to tune activities and modulate necroptotic signaling flux.
View Article and Find Full Text PDFEcotoxicol Environ Saf
December 2024
School of Life Sciences, Xiangya School of Medicine, Central South University, Changsha 510006, China. Electronic address:
Diisooctyl phthalate (DIOP), a common phthalate plasticizer, is frequently encountered in everyday life. Despite its widespread use, there is a dearth of toxicological research on DIOP, resulting in incomplete knowledge of its potential harmful effects. Our current research endeavored to provide a comprehensive evaluation of DIOP's toxicological profile using both cellular and Caenorhabditis elegans models as our in vitro and in vivo study subjects.
View Article and Find Full Text PDFCurr Pharm Teach Learn
December 2024
Institute of Public Health, The University of Jordan, Amman, Jordan; Honorary Research Fellow-Department of Primary Care and Public Health-Faculty of Medicine-Imperial College London, London, United Kingdom. Electronic address:
Background: The licensing or authorisation of medicines is an essential legal and regulatory procedure that permits the commercial distribution and availability of medical products and devices. Regulatory affairs pharmacists play a major role in licensing and regulating pharmaceutical products and medical devices. Therefore, it is necessary to ensure that regulatory affairs pharmacists are sufficiently competent to practise.
View Article and Find Full Text PDFPLoS Negl Trop Dis
December 2024
Life Science Research Centre, Faculty of Science, University of Ostrava, Ostrava, Czechia.
Leishmania is a genus of the family Trypanosomatidae that unites obligatory parasitic flagellates causing a variety of vector-borne diseases collectively called leishmaniasis. The symptoms range from relatively innocuous skin lesions to complete failures of visceral organs. The disease is exacerbated if a parasite harbors Leishmania RNA viruses (LRVs) of the family Pseudototiviridae.
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