AI Article Synopsis
- Restraint stress during acute infection with Theiler's virus leads to lowered immune response due to increased corticosterone levels in mice.
- Chemokine levels were analyzed in the spleen and central nervous system, revealing specific mRNAs present in the spleen but absent in the brain after two days post-infection.
- By day seven, certain chemokines increased in both organs, but restraint stress diminished these levels in the brain and reduced inflammation in the central nervous system.
Article Abstract
Restraint stress (RS) applied to mice during acute infection with Theiler's virus causes corticosterone-induced immunosuppression. This effect was further investigated by measuring chemokine changes in the spleen and central nervous system (CNS) using an RNase Protection Assay. mRNAs for lymphotactin (Ltn), interferon-induced protein-10 (IP-10), MIP-1 beta, monocyte chemoattractant protein-1 (MCP-1) and TCA-3 were detected in the spleen at day 2 pi, but not in the brain of CBA mice infected with Theiler's virus. Ltn, IP-10 and RANTES were elevated in both the spleen and the brain at day 7 pi, and were significantly decreased by RS in the brain. RS also resulted in decreased inflammation within the CNS.
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| http://dx.doi.org/10.1016/j.jneuroim.2004.02.010 | DOI Listing |
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