Individuals can infer what others are likely to know by clustering knowledge according to common goals, common topics, or common underlying principles. Although young children are sensitive to underlying principles, that manner of clustering might not prevail when other viable means are presented. Two studies examined how a sample of 256 children at ages 5, 7, 9, and 11 decide how to generalize another person's knowledge when goals, topics, and principles are put in conflict. In both studies, younger children preferred generalizing according to goals and topics, whereas older children preferred clustering based on principles related to disciplines. The most naturalistic ways of envisioning how knowledge is clustered in the minds of others therefore seems to change significantly during the elementary school years.
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http://dx.doi.org/10.1111/j.1467-8624.2004.00714.x | DOI Listing |
J Neurochem
January 2025
Centre for Prions and Protein Folding Diseases, University of Alberta, Edmonton, Canada.
Highly abundant in neurons, the cellular prion protein (PrP) is an obligatory precursor to the disease-associated misfolded isoform denoted PrP that accumulates in the rare neurodegenerative disorders referred to either as transmissible spongiform encephalopathies (TSEs) or as prion diseases. The ability of PrP to serve as a substrate for this template-mediated conversion process depends on several criteria but importantly includes the presence or absence of certain endoproteolytic events performed at the cell surface or in acidic endolysosomal compartments. The major endoproteolytic events affecting PrP are referred to as α- and β-cleavages, and in this review we outline the sites within PrP at which the cleavages occur, the mechanisms potentially responsible and their relevance to pathology.
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Institute of Infection, Veterinary & Ecological Sciences, University of Liverpool, Liverpool, United Kingdom.
Salmonella enterica serovar Typhimurium is a prevalent food-borne pathogen that is usually associated with gastroenteritis infection. S. Typhimurium is also a major cause of bloodstream infections in sub-Saharan Africa, and is responsible for invasive non-typhoidal Salmonella (iNTS) disease.
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Universidad de Chile, Departamento de Sanidad Vegetal, Facultad de Ciencias Agronomicas, Casilla 1004, Santiago, Chile, 8820000;
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Henan Normal University, College of Life Sciences, Xinxiang, Xinxiang, Henan, China, 453007.
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