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Strain diversity and host specificity of the gut symbiont Gilliamella in Apis mellifera, Apis cerana and Bombus terrestris.
Microbiol Res
January 2025
College of Animal Sciences, Zhejiang University, Hangzhou 310058, China. Electronic address:
Social bees, with their specialized gut microbiota and societal transmission between individuals, provide an ideal model for studying host-gut microbiota interactions. While the functional disparities arising from strain-level diversity of gut symbionts and their effects on host health have been studied in Apis mellifera and bumblebees, studies focusing on host-specific investigations of individual strains across different honeybee hosts remain relatively unexplored. In this study, the complete genomic sequences of 17 strains of Gilliamella from A.
View Article and Find Full Text PDFBorn of frustration: the emergence of Camelina sativa as a platform for lipid biotechnology.
Plant Physiol
January 2025
Rothamsted Research, West Common, Harpenden, Al5 2JQ, UK.
The emerging crop Camelina sativa (L.) Crantz (camelina) is a Brassicaceae oilseed with a rapidly growing reputation for the deployment of advanced lipid biotechnology and metabolic engineering. Camelina is recognised by agronomists for its traits including yield, oil/protein content, drought tolerance, limited input requirements, plasticity and resilience.
View Article and Find Full Text PDFCan We Ever Develop an Ideal RNA Force Field? Lessons Learned from Simulations of the UUCG RNA Tetraloop and Other Systems.
J Chem Theory Comput
January 2025
Institute of Biophysics of the Czech Academy of Sciences, Královopolská 135, 612 00 Brno, Czech Republic.
Molecular dynamics (MD) simulations are an important and well-established tool for investigating RNA structural dynamics, but their accuracy relies heavily on the quality of the employed force field (). In this work, we present a comprehensive evaluation of widely used pair-additive and polarizable RNA s using the challenging UUCG tetraloop (TL) benchmark system. Extensive standard MD simulations, initiated from the NMR structure of the 14-mer UUCG TL, revealed that most s did not maintain the native state, instead favoring alternative loop conformations.
View Article and Find Full Text PDFScreening of an antimicrobial peptide-TWPAL and its application in hydrogels for wound healing.
J Mater Chem B
January 2025
School of Materials Science and Engineering, Shandong University of Technology, Zibo, 255000, China.
Open wounds are one of the concerns of modern medicine. Early on, before the wound has closed, bacteria can easily enter, leading to bacterial infections. Excipients with antimicrobial effects can greatly facilitate the wound healing process.
View Article and Find Full Text PDFParallel EEG-fNIRS assessments of covert cognition in behaviorally non-responsive ICU patients: A multi-task feasibility study in a case of acute motor sensory axonal neuropathy.
J Neurol
January 2025
Western Institute of Neuroscience, Western University, London, Canada.
Background: Repeat neurological assessment is standard in cases of severe acute brain injury. However, conventional measures rely on overt behavior. Unfortunately, behavioral responses may be difficult or impossible for some patients.
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