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Identifying an effective Chinese herbal medicine for reducing postoperative hidden bleeding and stabilizing blood volume following intertrochanteric femur fracture: a Bayesian network meta-analysis of randomized controlled trials.
J Orthop Surg Res
December 2024
Department of Orthopaedics, Fuzhou Second General Hospital, Fujian Medical University, Fuzhou, 350007, China.
Objective: Chinese herbal medicine (CHM) is extensively utilized in managing hidden bleeding following an intertrochanteric femur fracture (IFF). Despite its widespread use, the most effective CHM approach for addressing hidden bleeding post-IFF remains unclear. A Bayesian network meta-analysis was conducted to identify a CHM that both effectively reduces hidden bleeding and stabilizes blood volume after IFF.
View Article and Find Full Text PDFEfficacy and Safety of Yangxue Qingnao Pills Combined with Amlodipine in Treatment of Hypertensive Patients with Blood Deficiency and Gan-Yang Hyperactivity: A Multicenter, Randomized Controlled Trial.
Chin J Integr Med
November 2024
Department of the Cardiology, Chinese PLA General Hospital, Beijing, 100853, China.
Article Synopsis
- The study aimed to assess the effectiveness and safety of Yangxue Qingnao Pills (YXQNP) when used alongside amlodipine for treating grade 1 hypertension in patients with specific syndrome symptoms.
- Conducted as a multicenter, randomized, double-blind trial, 662 participants were split into treatment and control groups, receiving either the YXQNP or a placebo alongside the standard medication for 180 days, with their health outcomes carefully monitored.
- Results showed that the treatment group had better improvements in blood pressure, associated symptoms like dizziness and headache, and overall clinical syndrome scores without any significant adverse effects, indicating that the combination therapy could be a beneficial approach for managing hypertension.
An endophenotype network strategy uncovers YangXue QingNao Wan suppresses Aβ deposition, improves mitochondrial dysfunction and glucose metabolism.
Phytomedicine
December 2024
Science and Technology Innovation Center, Guangzhou University of Chinese Medicine, Guangzhou, 510405, China. Electronic address:
Article Synopsis
- Alzheimer's disease (AD) is a significant health challenge with limited treatments, and YangXue QingNao Wan (YXQNW) is a TCM formula being tested for its effectiveness against AD in clinical trials.
- This study investigates the anti-AD properties of YXQNW through an innovative endophenotype network strategy, identifying active ingredients and clarifying their therapeutic mechanisms.
- Results show a strong correlation between YXQNW's effects and amyloid β levels, indicating its potential role in addressing AD's pathology.
Yiqi Yangxue formula inhibits cartilage degeneration in knee osteoarthritis by regulating LncRNA-UFC1/miR-34a/MMP-13 axis.
J Ethnopharmacol
January 2025
The Second Clinical Medical College, Zhejiang Chinese Medical University, Hangzhou, 310000, China; School of Basic Medical Sciences, Yunnan University of Chinese Medicine, Kunming, 650500, China. Electronic address:
Article Synopsis
- Knee osteoarthritis (KOA) is a common and debilitating condition, and the Yiqi Yangxue formula (YQYXF) is often used to treat it, though research on its epigenetic effects and role of non-coding RNA is limited.
- The study investigates how YQYXF impacts the long chain non-coding RNA UFC1, miR-34a, and matrix metalloproteinase-13 (MMP-13), looking at their interactions and significance in KOA.
- Using various methods including UHPLC-QE-MS technology and RT-PCR, researchers found that YQYXF contains key compounds like flavonoids and phenylpropanoids that potentially influence the expression of genes related to
[Chemical components and in vitro anti-aging activity of Yangxue Qingnao Wan based on UPLC-Q-TOF-MS/MS].
Zhongguo Zhong Yao Za Zhi
September 2024
The main chemical components of Yangxue Qingnao Wan(YXQNW) were analyzed and identified by ultra-performance liquid chromatography-quadrupole-time-of-flight mass spectrometry(UPLC-Q-TOF-MS/MS). According to the mass spectrometry information, Mass Hunter 10.0 analysis software was used to compare the collected quasi-molecular ion peaks and secondary fragment ions with literature and reference substances.
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