Objective: That static ear canal air pressure (ECP) influences the frequency of spontaneous otoacoustic emissions (SOAEs) suggests that it may influence intracochlear, in addition to middle ear, processes. A previous study suggested that ECP influences pure tone pitch perception at 1,000 Hz, which was interpreted as indicating an effect on the cochlear place-frequency map. The present study extended investigations of this effect to 500 and 4,000 Hz.
Material And Methods: Nine normal-hearing listeners performed interaural pitch matching with monaural ECPs of 0 and -300 daPa.
Results: Some indications of a small downward pitch shift (mean 0.2%) at 500 Hz were observed, which were marginally statistically significant at the 5% level. No pitch shifts were observed at 4,000 Hz.
Conclusions: ECP does not influence pitch to the extent suggested previously or by SOAE frequency shifts. No evidence was found to support the notion that ECP influences the place-frequency map.
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http://dx.doi.org/10.1080/00016480310000511 | DOI Listing |
Cureus
January 2025
Ophthalmology, Royal Free Hospital, London, GBR.
Endoscopic cyclophotocoagulation (ECP) offers a viable alternative for managing advanced primary open-angle glaucoma (POAG) in patients at risk of ocular hypotony. We describe a case of a successful outcome with ECP in a patient who developed ocular hypotony secondary to Preserflo surgery. A 93-year-old South Asian male experienced significant visual field deterioration and ocular hypotony following Preserflo surgery on the left eye, complicated by a severe cough from COVID-19.
View Article and Find Full Text PDFBMC Pediatr
January 2025
Department of Pediatrics, Faculty of Medicine, Assiut University, Egypt, 71515, Assiut, Egypt.
Background: This study aimed to investigate the possible association of LPCAT1-rs8352 genetic variant (single nucleotide change C to G) with the onset and severity of pediatric asthma. Additionally, the study examined the influence of LPCAT1-rs8352 genotypes on asthma-related biomarkers including blood eosinophils count (BEC), eosinophil cationic protein (ECP), high-sensitivity C-reactive protein (hs-CRP), and immunoglobulin E (IgE) and on lung function [forced expiratory volume in one second (FEV1) and the forced vital capacity (FVC)].
Patients And Methods: The study included ninety-six participant grouped into two groups: G1 (46 asthmatics) and G2 (50 healthy controls).
Transplant Proc
January 2025
Nefrology Department, Universitary Hospital Virgen de la Arrixaca, Murcia, Spain.
T-cell mediated rejection (TCMR) in renal transplantation, although reduced by better immunosuppressants, still impacts graft survival. TCMR responds to methylprednisolone (MPL) in 60% to 70% of cases, with polyclonal anti-T-lymphocyte antibodies (ATGs) used for severe or corticoresistant cases. When ATG is contraindicated, extracorporeal photopheresis (ECP) may be an alternative.
View Article and Find Full Text PDFAm J Transl Res
December 2024
Department of Otolaryngology, Air Force Hospital of The Central Theater Command of PLA Datong 037006, Shanxi, China.
Objectives: To identify the risk factors for postoperative relapse of chronic rhinosinusitis with nasal polyps (CRSwNP) using multivariate Logistic regression analysis and to explore potential improvements in clinical treatment measures.
Methods: We selected 270 CRSwNP patients who underwent surgery at The First People's Hospital of Jiangxia District between January 2022 and July 2024. The patients were divided into two groups based on the presence or absence of postoperative relapse: 40 cases with relapse were designated as the relapse group, and the other 230 cases without relapse were designated as the non-relapse group.
Mater Today Bio
February 2025
Discipline of Mechanical, Manufacturing and Biomedical Engineering, School of Engineering, Trinity College Dublin, Dublin 2, Ireland.
Peripheral nerve repair (PNR) is a major healthcare challenge due to the limited regenerative capacity of the nervous system, often leading to severe functional impairments. While nerve autografts are the gold standard, their implications are constrained by issues such as donor site morbidity and limited availability, necessitating innovative alternatives like nerve guidance conduits (NGCs). However, the inherently slow nerve growth rate (∼1 mm/day) and prolonged neuroinflammation, delay recovery even with the use of passive (no-conductive) NGCs, resulting in muscle atrophy and loss of locomotor function.
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