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Dietary Methionine Restriction Alleviates Cognitive Impairment in Alzheimer's Disease Mice via Sex-Dependent Modulation on Gut Microbiota and Tryptophan Metabolism: A Multiomics Analysis.
J Agric Food Chem
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Laboratory of Functional Chemistry and Nutrition of Food, College of Food Science and Engineering, Northwest A&F University, Yangling, Shaanxi 712100, China.
Plant-based foods with low methionine contents have gained increasing interest for their potential health benefits, including neuroprotective effects. Methionine restriction (MR) linked to a plant-based diet has been shown to mitigate neurodegenerative diseases such as Alzheimer's disease (AD) through mechanisms that involve the gut microbiota. In this study, a 16-week MR diet (0.
View Article and Find Full Text PDFImpact of the probiotic on loperamide-induced delayed bowel movement in Sprague-Dawley rats.
Food Funct
January 2025
Institute of Human Behavior & Genetics, Korea University, Seoul 02841, Republic of Korea.
This study investigated the effects of on alleviating loperamide-induced constipation. To evaluate the efficacy of in Sprague-Dawley (SD) rats, fecal parameters, the intestinal transit rate, and changes in intestinal mucosal cells were measured through histological analysis. Additionally, serotonin levels, water absorption, tight junction-related gene expression, and the cecal short-chain fatty acid (SCFA) content were analyzed.
View Article and Find Full Text PDFThe Potential of an Artificially Ultraviolet B Irradiated Hay as a Source of Vitamin D.
J Anim Physiol Anim Nutr (Berl)
January 2025
Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, Helsinki, Finland.
Roughage can be a significant source of vitamin D in herbivore diets. The vitamin D content of forages can vary considerably and depends, among others, on plant species, plant maturity and climate fluctuations. Ultraviolet B (UVB) exposure causes conversion of provitamin D to vitamin D and thus represents the most important influence.
View Article and Find Full Text PDFPredictive models of post-prandial glucose response in persons with prediabetes and early onset type 2 diabetes: A pilot study.
Diabetes Obes Metab
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Department of Medicine, Division of Endocrinology, Diabetes Research Center, Columbia University Irving Medical Center, New York, New York, USA.
Objective: Post-prandial glucose response (PPGR) is a risk factor for cardiovascular disease. Meal carbohydrate content is an important predictor of PPGR, but dietary interventions to mitigate PPGR are not always successful. A personalized approach, considering behaviour and habitual pattern of glucose excursions assessed by continuous glucose monitor (CGM), may be more effective.
View Article and Find Full Text PDFAnalysis of User-Generated Posts on Social Media of Adjuvant Analgesics: A Machine Learning Study.
Int J Med Sci
January 2025
Department of Medicine and Medical Specialities. University of Alcala, Alcala de Henares, 28801 Madrid, Spain.
Antiepileptics and antidepressants are frequently prescribed for chronic pain, but their efficacy and potential adverse effects raise concerns, including dependency issues. Increased prescriptions, sometimes fraudulent, prompted reclassification of antiepileptics in some countries. Our aim is to comprehend opinions, perceptions, beliefs, and attitudes towards co-analgesics from online discussions on X (formerly known as Twitter), offering insights closer to reality than conventional surveys.
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