Quality of life (QOL) is an index of the state of wellness of an individual. The purpose of this study was to develop an instrument to measure quality of life of patients with hyperhidrosis. With a multi- dimensional model of QOL as the conceptual framework for instrument development, the study started from literature review which was followed by interviews with patients, staff nurses, and doctors to generate the original items for the instrument. The validity and reliability then were assessed. Six experts performed content validity (CVI =.70). Internal consistency and construct validity assessment followed. A quantitative research method was used in this study. During March 2002 to April 2003, 85 patients from the surgical outpatient clinic at a teaching hospital in southern Taiwan were purposively recruifed as subjects. Written consent was obtained before subjects answered a questionnaire that should take 8-10 minutes to finish. Data analysis was performed using SPSS for Windows 8.0. Mean, standard deviation, frequency, percentage, Cronbach ' s alpha, Pearson ' s correlation, and factor analysis were used to analyze the data. Exploratory factor analysis identified five factors. They were functional, social interaction, personal affective, psychological and physical function. The coefficients of Cronbach ' s alpha for these five factors ranged from 0.71 to 0.94. These five factors explained 68.90 % of the variance in QOL among the patients with hyperhidrosis. The results showed that the instrument had satisfactory validity and reliability. Implications of these results for future studies were discussed.
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http://dx.doi.org/10.1097/01.jnr.0000387485.78685.1e | DOI Listing |
Sci Rep
December 2024
Department of Neurobiology and Behavior, University of California Irvine, Irvine, CA, 92697, USA.
Preserving the ability to vividly recall emotionally rich experiences contributes to quality of life in older adulthood. While prior works suggest that moderate-intensity physical activity (MPA) may bolster memory, it is unclear whether this extends to emotionally salient memories consolidated during sleep. In the current study, older adults (mean age = 72.
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December 2024
Nehme and Therese Tohme Multiple Sclerosis Center, American University of Beirut Medical Center, Riad El-Solh, PO Box 11-0236, 1107 2020, Beirut, Lebanon.
Fatigue is one of the most prevalent and disabling symptoms among patients with MS, but there is limited research investigating the longitudinal determinants of fatigue progression. This study aims to identify the sociodemographic, behavioral and clinical characteristics, and therapeutic regimens that are correlated with worsening fatigue over time in patients diagnosed with MS. This is a retrospective chart review of 483 patients.
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December 2024
State Key Laboratory of Quality Research in Chinese Medicine, Institute of Chinese Medical Sciences, University of Macau, Macau, China.
Lipid nanoparticles (LNPs) have proven effective in mRNA delivery, as evidenced by COVID-19 vaccines. Its key ingredient, ionizable lipids, is traditionally optimized by inefficient and costly experimental screening. This study leverages artificial intelligence (AI) and virtual screening to facilitate the rational design of ionizable lipids by predicting two key properties of LNPs, apparent pKa and mRNA delivery efficiency.
View Article and Find Full Text PDFsurgery for rectal cancer often presents multiple tactical and technical challenges due to factors such as the tumor's extent, limited anatomical space, proximity to the anal sphincter complex, and the use of neoadjuvant radiotherapy. These factors can significantly increase the complexity of surgery and the risk of both immediate and delayed complications, which can occur intraoperatively or postoperatively. Objective: the aim of this study was to retrospectively analyze the causes, diagnostic methods, and management of complications in patients who underwent surgery for rectal cancer.
View Article and Find Full Text PDFcolorectal cancer is a common and serious condition, with surgical resection being the primary treatment for localized cases. Anastomotic dehiscence (AD) remains a significant postoperative complication, and anastomoses are typically created using either manual suturing or mechanical stapling, each with specific benefits and challenge. Material and this retrospective study analyzed outcomes in 100 rectal cancer patients who underwent surgical resection, with anastomoses performed via manual suturing (n=50) or mechanical stapling (n=50).
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