Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1378/chest.125.5_suppl.101s | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Inhibition of Benzo[a]pyrene-induced DNA Adduct in Buccal Cells of Smokers by Black Raspberry Lozenges.
Carcinogenesis
October 2024
Department of Biochemistry and Molecular Biology, Penn State College of Medicine, Hershey, PA.
Article Synopsis
- Researchers previously found that benzo[a]pyrene (B[a]P), a carcinogen in tobacco smoke, caused significantly more DNA damage in smokers' buccal cells compared to non-smokers, indicating a link to oral squamous cell carcinoma (OSCC).
- A Phase 0 clinical study involving 27 smokers tested the effects of black raspberry (BRB) lozenges on reducing B[a]P-induced DNA damage over an 8-week period.
- Results showed a significant reduction in DNA damage at various points during and after BRB administration, suggesting its potential as a chemopreventive agent against tobacco-related OSCC.
Long Noncoding RNA PSMB8-AS1 Mediates the Tobacco-Carcinogen-Induced Transformation of a Human Bronchial Epithelial Cell Line by Regulating Cell Cycle.
Chem Res Toxicol
June 2024
School of Public Health, Guangzhou Medical University, Guangzhou 511436, P. R. China.
Lung cancer is the main cause of cancer deaths around the world. Nitrosamine 4-(methyl nitrosamine)-1-(3-pyridyl)-1-butanone (NNK) is a tobacco-specific carcinogen of lung cancer. Abundant evidence implicates long noncoding RNAs (lncRNAs) in tumorigenesis.
View Article and Find Full Text PDFLncRNA XIST modulates miR-328-3p ectopic expression in lung injury induced by tobacco-specific lung carcinogen NNK both in vitro and in vivo.
Br J Pharmacol
August 2024
School of Traditional Chinese Materia Medica, Key Laboratory of Innovative Traditional Chinese Medicine for Major Chronic Diseases of Liaoning Province, Key Laboratory for TCM Material Basis Study and Innovative Drug Development of Shenyang City, Shenyang Pharmaceutical University, Shenyang, China.
Background And Purpose: It is well acknowledged that tobacco-derived lung carcinogens can induce lung injury and even lung cancer through a complex mechanism. MicroRNAs (MiRNAs) are differentially expressed in tobacco-derived carcinogen nicotine-derived nitrosamine ketone (NNK)-treated A/J mice.
Experimental Approach: RNA sequencing was used to detect the level of long non-coding RNAs (lncRNAs).
Fat intake modifies association between cigarette smoking and lung cancer in a prospective cohort study: A potential explanation for the lung cancer paradox.
Clin Nutr
April 2024
Department of Epidemiology, Indiana University Richard M. Fairbanks School of Public Health, Indianapolis, IN, USA; Indiana University Melvin and Bren Simon Comprehensive Cancer Center, Indianapolis, IN, USA. Electronic address:
Background & Aims: It remains unclear why the association between cigarette smoking and lung cancer was substantially stronger in Western countries than in Asian countries. As experimental studies have revealed that fat intake modulates tobacco carcinogen metabolism and the growth of transplanted or carcinogen-induced lung tumors in mice, the present study sought to investigate whether the association between cigarette smoking and lung cancer was modified by intake of total fat and types of fat (saturated, monounsaturated, and polyunsaturated fats) in the Prostate, Lung, Colorectal, and Ovarian Cancer Screening Trial.
Methods: During a median follow-up of 8.
Gender Difference in DNA Damage Induced by the Environmental Carcinogen Dibenzo[]chrysene Individually and in Combination with Mouse Papillomavirus Infection in the Mouse Oral Cavity.
ACS Omega
February 2024
Department of Biochemistry & Molecular Biology, Penn State College of Medicine, Hershey, Pennsylvania 17033-2360, United States.
Tobacco smoking and human papillomavirus infection are established etiological agents in the development of head and neck squamous cell carcinoma (HNSCC). The incidence and mortality of HNSCC are higher in men than women. To provide biochemical basis for sex differences, we tested the hypothesis that carcinogen treatment using dibenzo[]chrysene, which is an environmental pollutant and tobacco smoke constituent, in the absence or presence of the mouse papillomavirus infection results in significantly higher levels of DNA damage in the oral cavity in male than in female mice.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!