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Knockdown of an ATP-binding cassette transporter in resistant western corn rootworm larvae partially reverses resistance to eCry3.1Ab protein.
Sci Rep
December 2024
Division of Plant Science and Technology, University of Missouri, Columbia, MO, 65211, USA.
The western corn rootworm (WCR), Diabrotica virgifera virgifera LeConte, has evolved resistance to nearly every management tactic utilized in the field. This study investigated the resistance mechanisms in a WCR strain resistant to the Bacillus thuringiensis (Bt) protein eCry3.1Ab using dsRNA to knockdown WCR midgut genes previously documented to be associated with the resistance.
View Article and Find Full Text PDFpiggyBac-based transgenic Helicoverpa armigera expressing the T92C allele of the tetraspanin gene HaTSPAN1 confers dominant resistance to Bacillus thuringiensis toxin Cry1Ac.
Pestic Biochem Physiol
September 2024
College of Plant Protection, Nanjing Agricultural University, Nanjing 210095, China. Electronic address:
Transgenic crops producing insecticidal proteins from Bacillus thuringiensis (Bt) have revolutionized pest control. However, the evolution of resistance by target pests poses a significant threat to the long-term success of Bt crops. Understanding the genetics and mechanisms underlying Bt resistance is crucial for developing resistance detection methods and management tactics.
View Article and Find Full Text PDFDisruption to uridine biosynthesis alters β-1,3-glucan masking in .
mSphere
September 2024
Department of Microbiology, University of Tennessee, Knoxville, Tennessee, USA.
The uridine derivatives UDP-glucose and UDP--acetylglucosamine are important for cell wall construction as they are the precursors for the synthesis of β-1,3-glucan and chitin, respectively. Previous studies have demonstrated attenuated virulence of uridine auxotrophs in mice, which has been attributed to insufficient uridine levels for growth in the host. We have discovered that uridine deprivation in the uridine auxotroph ΔΔ disrupts cell wall architecture by increasing surface mannans, exposing β-1,3-glucan and chitin, and decreasing UDP-sugar levels.
View Article and Find Full Text PDFEffects of combining soil-applied insecticide and Bt corn for integrated pest management and resistance management of western corn rootworm (Coleoptera: Chrysomelidae).
J Econ Entomol
October 2024
Department of Plant Pathology, Entomology and Microbiology, Iowa State University, Ames, IA, USA.
The western corn rootworm, (Diabrotica virgifera virgifera LeConte, Coleoptera: Chrysomelidae), is a serious pest of corn (Zea mays Linnaeus, Cyperales: Poaceae) in the midwestern United States. Management practices for corn rootworm larvae include crop rotation, transgenic corn producing insecticidal toxins from the bacterium Bacillus thuringiensis Berliner (Bacillales: Bacillaceae) (Bt), and soil-applied insecticides. The extent to which combining soil-applied insecticide with Bt corn would be beneficial from the perspective of insect resistance management (IRM) or integrated pest management (IPM) remains uncertain.
View Article and Find Full Text PDFRNA modification gene WDR4 facilitates tumor progression and immunotherapy resistance in breast cancer.
J Adv Res
July 2024
State Key Laboratory of Oncology in South China, Guangdong Provincial Clinical Research Center for Cancer, Sun Yat-Sen University Cancer Center, 651, East Dongfeng Road, Guangzhou 510060, China. Electronic address:
Article Synopsis
- The study investigates the role of RNA modifications in breast cancer to improve predictions of therapy response and patient survival.
- Researchers created a nine-gene signature, called RMscore, based on thirteen RNA modification patterns to assess the tumor immune microenvironment and treatment outcomes.
- Findings suggest that a high RMscore indicates a suppressive immune environment and resistance to treatments, and targeting the gene WDR4 could significantly hinder breast cancer growth.
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