We examined the angiotensin I-converting enzyme (ACE) inhibitory activity and antihypertensive effect of the hot water extract of wakame, Undaria pinnatifida. Ten dipeptides were isolated from the extract by several steps of chromatography, and their amino acid sequences were Tyr-His, Lys-Trp, Lys-Tyr, Lys-Phe, Phe-Tyr, Val-Trp, Val-Phe, Ile-Tyr, Ile-Trp, and Val-Tyr. Both single administration and repeated oral administration of synthetic Tyr-His, Lys-Tyr, Phe-Tyr, and Ile-Tyr significantly decreased blood pressure in spontaneously hypertensive rats.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.jnutbio.2003.11.004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Undaria pinnatifida fucoidan extract inhibits activation of the NF-κB signaling pathway by herpes simplex virus type 1 and prevents amyloid-β peptide synthesis in retinal pigment epithelium cells.
Arch Virol
January 2025
Departamento de Biología, Bioquímica y Farmacia, Universidad Nacional del Sur-Bahía Blanca, Buenos Aires, Argentina.
Neurodegenerative pathologies such as age-related macular degeneration currently have no cure or effective treatment. In this type of disease, the presence of amyloid-β peptides, oxidative stress, and inflammation trigger dysregulation of retinal pigment epithelial cells and progression toward the death of these cells, resulting in a loss of vision. The production of amyloid-β peptides, oxidative stress, and inflammation can be triggered in response to viral infections.
View Article and Find Full Text PDFSynergistic production of nitrogen-rich hydrochar and solid biofuels via co-hydrothermal carbonization of microalgae and macroalgae: when nitrogen circularity matters.
Environ Res
January 2025
Thermochemical Processes Group, Aragón Institute for Engineering Research (I3A), University of Zaragoza, C/Mariano Esquillor s/n, 50.018, Zaragoza, Spain. Electronic address:
This work explores the synergies between N-rich (Chlorella pyrenoidosa) and N-deficient (Undaria pinnatifida) macroalgae for the production of N-containing hydrochar and solid biofuels via co-hydrothermal carbonization (co-HTC). The impact of the feedstock (each alga alone and all possible binary mixtures) was comprehensively assessed under different temperatures (180-260 °C) and times (60-240 min). The synergies between micro and macroalgae governed product distribution, nitrogen transformation pathways, and hydrochar quality, with these effects varying by processing conditions.
View Article and Find Full Text PDFThe Beneficial Roles of Seaweed in Atopic Dermatitis.
Mar Drugs
December 2024
Department of Smart Green Technology Engineering, Pukyong National University, Busan 48513, Republic of Korea.
Atopic dermatitis (AD) is a chronic, inflammatory skin condition characterized by severe pruritus and recurrent flare-ups, significantly impacting patients' quality of life. Current treatments, such as corticosteroids and immunomodulators, often provide symptomatic relief but can lead to adverse effects with prolonged use. Seaweed, a sustainable and nutrient-dense resource, has emerged as a promising alternative due to its rich bioactive compounds-polysaccharides, phlorotannins, polyphenols, and chlorophyll-that offer anti-inflammatory, antioxidant, and immunomodulatory properties.
View Article and Find Full Text PDFextract attenuates combined allergic rhinitis and asthma syndrome by the modulation of epithelial cell dysfunction and oxidative stress.
Acta Biochim Biophys Sin (Shanghai)
December 2024
Department of Anatomy, Jeonbuk National University Medical School, Jeonju 54896, Republic of Korea.
( . ) has long been a part of the human diet and medicine. Although .
View Article and Find Full Text PDFBioactive Compounds of Sea Mustard () Waste Affected by Drying Methods.
Foods
November 2024
Department of Food Science and Technology, Sunchon National University, Suncheon 57922, Jeonnam, Republic of Korea.
Sea mustard () is a brown macroalga extensively cultivated and consumed in South Korea. However, the high volume of seaweed production in the country results in substantial waste generation. To mitigate this issue, the bioactive compounds of sea mustard waste parts (sporophyll, root, and stem) were assessed under different drying conditions (freeze, oven, and microwave drying) to evaluate their potential as functional ingredients.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!