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A broadly applicable protein-polymer adjuvant system for antiviral vaccines.
EMBO Mol Med
June 2024
National Key Laboratory of Agricultural Microbiology, Huazhong Agricultural University, Wuhan, 430070, China.
Although protein subunit vaccines generally have acceptable safety profiles with precise antigenic content, limited immunogenicity can lead to unsatisfactory humoral and cellular immunity and the need for vaccine adjuvants and delivery system. Herein, we assess a vaccine adjuvant system comprising Quillaja Saponaria-21(QS-21) and cobalt porphyrin polymeric micelles that enabling the display of His-tagged antigen on its surface. The nanoscale micelles promote antigen uptake and dendritic cell activation to induce robust cytotoxic T lymphocyte response and germinal center formation.
View Article and Find Full Text PDFViral Diseases in Water Buffalo (): New Insights and Perspectives.
Animals (Basel)
March 2024
Laboratorio de Parasitología, Facultad de Medicina Veterinaria y Zootecnia, Universidad Veracruzana, Colonia Unidad Veracruzana, Veracruz 91710, Veracruz, Mexico.
The water buffalo () has great adaptability to rustic environments and more variable conditions than cattle, who generally share the habitat. Diseases carried by buffaloes are relatively unknown and ignored and could be transmissible; an imbalance occurs between pathogens, environment, and susceptible hosts, generating a severe animal health problem. Also relevant is the effect of climate change on the populations of vectors that transmit viral diseases.
View Article and Find Full Text PDFAnte-mortem and Post-mortem Diagnosis Modalities and Phylogenetic Analysis of Rabies Virus in Domestic and Wild Animals of Gujarat, India.
Indian J Microbiol
December 2023
Department of Animal Biotechnology, College of Veterinary Science and Animal Husbandry, Sardarkrushinagar Dantiwada Agricultural University (Now Under Kamdhenu University), Sardarkrushinagar, Banaskantha, Gujarat 385005 India.
Unlabelled: In the present study, total of 32 ante-mortem (AM) samples (saliva = 18 and corneal smears = 14) from six animal species (cattle = 5; camel = 1; goat = 1; horse = 1; buffalo = 4; dog = 6) and 28 post-mortem (PM) samples of domestic (cattle = 6; camel = 1; goat = 1; buffalo = 5; dog = 7) and wild animals (lion = 4, mongoose = 2; bear = 1; leopard = 1) were examined for rabies diagnosis in Gujarat, India. Direct fluorescent antibody test (dFAT) and reverse transcriptase polymerase chain reaction (RT-PCR) were applied on AM samples, whereas along with dFAT and RT-PCR, histopathological examination, immunohistochemistry (IHC) and real time PCR (qPCR) were used for PM diagnosis. Nucleotide sequencing of full nucleoprotein (N) and glycoprotein (G) genes were carried out upon representative amplicons.
View Article and Find Full Text PDFRisk mapping and risk factors analysis of rabies in livestock in Bangladesh using national-level passive surveillance data.
Prev Vet Med
October 2023
Center for Animal Disease Modeling and Surveillance (CADMS), Department of Medicine & Epidemiology, School of Veterinary Medicine, University of California, Davis, CA, USA. Electronic address:
Article Synopsis
- * A study analyzed rabies cases reported in livestock across Bangladesh from 2015 to 2017, finding that higher monsoon rainfall and lower education levels were linked to increased rabies cases.
- * The research produced risk maps indicating high rabies risk in southeastern Bangladesh and recommends targeted vaccination for dogs and jackals in these areas to mitigate the disease's impact.
Recurrence of Herpetic Keratitis after COVID-19 Vaccination: A Report of Two Cases.
Case Rep Ophthalmol Med
May 2022
Ross Eye Institute, Department of Ophthalmology, Jacobs School of Medicine and Biomedical Sciences, State University at Buffalo, Buffalo, New York, USA.
Background: Recurrence of herpetic keratitis following vaccination has been documented following vaccination with the Zostavax, trivalent flu, hepatitis A, and rabies vaccines. The USFDA and WHO have acknowledged that the novel COVID-19 vaccines similarly have a risk of reactive immunologic-based inflammation, namely, myositis, pericarditis, and Guillain-Barré syndrome. .
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