Stability studies on the SPf66 antimalarial peptide with different pH and temperature conditions were carried out. The degradation mechanism was elucidated by the size-exclusion chromatography (SEC) technique and the experimental data obtained at 37 degrees C and different pH were fitted to a kinetic degradation model that could explain the loss of its immunogenic capacity. At 5, 25, 37, and 70 degrees C and pH 2, changes were detected in the areas of the different species, although the values obtained could not be fitted to any known degradation kinetics.
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a 1 Fundación Instituto de Inmunología de Colombia (FIDIC) , Carrera 50 # 26-20, Bogotá, Colombia +57 1 4815219 ; +57 1 4815269 ;
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