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IGF-I system responses during 12 weeks of resistance training in end-stage renal disease patients. | LitMetric

AI Article Synopsis

  • The study aimed to investigate how 12 weeks of resistance training affects key components of the IGF-I system in patients with end-stage renal disease (ESRD).
  • Ten ESRD patients participated in resistance training for 12 weeks after a 6-week control period, with blood samples collected at specific intervals to analyze IGF-I levels and associated proteins.
  • Results showed that while total IGF-I levels declined significantly by week 12, the overall proportion of IGF-I forms remained unchanged, indicating that the training led to improved physical performance despite the decrease in IGF-I.

Article Abstract

Objective: To examine the hypothesis that 12 weeks of resistance training would alter circulating concentrations of IGF-I system components in end-stage renal disease (ESRD) patients.

Design: Ten ESRD patients underwent 12 weeks of resistance training after a 6 week control period and had morning fasted blood drawn on four occasions (weeks - 6, 0, 6, 12). Immunoassays were performed for serum total and free IGF-I, IGF binding proteins (IGFBPs) 2 and 3, and the acid labile subunit (ALS). Immunoaffinity depletion of ALS-based complexes allowed measurement of non-ternary (i.e., binary) IGF-I and IGFBP-3.

Results: Significant improvements in strength and functional performance were observed. All IGF-I measures were stable during the control period and no changes were observed for the first 6 weeks of resistance training. At week 12, total IGF-I (-15.4+/-28.9%), ternary IGF-I (-16.4+/-36.7%), and the IGF-I/IGFBP-3 ratio had significantly (p < or = 0.05) declined from week 0 values. No changes were observed for free IGF-I, IGFBPs 2 and 3, or the acid labile subunit. The proportion of IGF-I in ternary ( approximately 76.3+/-6.8%), non-ternary ( approximately 22.5+/-6.6%), and free ( approximately 1.2+/-0.5%) forms remained constant throughout the training.

Conclusions: 12 weeks of resistance training in ESRD patients induced a decline in total IGF-I, but did not alter the proportion of IGF-I circulating in free, ternary or non-ternary molecular complexes. The decline in IGF-I occurs in the presence of positive training adaptations on physical performance and we conclude that this response pattern appears to be reflective of favorable neuromuscular anabolic adaptations.

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Source
http://dx.doi.org/10.1016/j.ghir.2004.01.007DOI Listing

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