AI Article Synopsis
- A study used camel hydatid fluid antigen in an ELISA system to detect specific IgG and IgG1 antibodies in sera from 35 patients with cystic echinococcosis (CE), finding high sensitivities of 88.6% for IgG and 94.35% for IgG1.
- Patients with a strong immune response showed a significantly higher frequency of the HLA-DR3 gene, which is associated with IgG antibodies, and this gene was linked to more complicated cases of CE.
- The findings suggest that testing for IgG1 is more reliable for diagnosing CE, and genetic factors like HLA-DR3 should be considered for predicting patient outcomes.
Article Abstract
An ELISA system using crude camel hydatid fluid antigen was used to detect specific IgG and IgG1 in sera of 35 cystic echinococcosis (CE) patients in whom the distribution of class II HLA-DR3 and HLA-DR11 was determined. The recorded sensitivities were 88.6 % and 94.35 % for IgG and IgG1 respectively. In patients with high humoral immune response a statistically highly significant increased frequency of HLA-DR3 (P<0.01) was recorded for IgG with high relative risk value (RR=3.2) and reasonable etiologic fraction (EF=0.3), while HLA-DR11 recorded P<0.05, RR=2.6, & EF=0.2. For IgG1 both antigens showed significant increased frequency (P<0.05), RR (2.95 & 2.79 respectively), EF (0.28 & 0.23 respectively). HLA-DR3 was highly significantly associated with complicated cases (P<0.01, RR=4.36, EF=0.4) in whom the mean antibody units for both IgG and IgG1 were significantly raised (P<0.05). It is advisable to rely on IgG1 for the diagnosis of CE and to consider the genetic disposition of the patient as an important criterion in the outcome of infection.
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