Inhibition of proliferation of normal and transformed neural cells by blood group-related oligosaccharides.

J Exp Med

Instituto Cajal, Consejo Superior de Investigaciones Científicas (CSIC), Madrid, Spain.

Published: September 1992

A synthetic tetrasaccharide structurally related to blood groups and selectin ligands inhibited division of astrocytes, gliomas, and neuroblastomas at micromolar concentrations. The compound was cytostatic for primary astrocytes in culture, but cytotoxic for fast proliferating cell lines.

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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC2119348PMC
http://dx.doi.org/10.1084/jem.176.3.915DOI Listing

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