Background: Juvenile angiofibroma (JA) is a rare tumor that occurs exclusively in adolescent male patients. The mainstay treatment for JA is complete surgical excision. Acceptable surgical approaches for the resection of JA include transantral, transpalatal, combined, endoscopic, and Le Fort I procedures, among others. Because exposure of the entire extension of the tumor may not possible, the recurrence rates after surgical treatment of JA may be as high as 55%. The purpose of this study was to evaluate the results after using the Le Fort I technique for the resection of JA.
Methods: We retrospectively studied 19 patients with JA submitted to surgical resection by using the Le Fort I approach from March 1983 to September 2002. Data regarding demographic characteristics, tumor topography, use of embolization, recurrence, and complication of treatment were obtained.
Results: Patient age at the time of diagnosis ranged from 8 to 26 years with a mean age of 16 years. The most common tumor site was the nasopharynx in 100% of the cases, pterygopalatine fossa (95%), nasal cavity (84%), and sphenoid sinus (63%). Angiography and embolization were performed preoperatively in 57% of the patients. The follow-up period ranged from 1 to 19 years (mean, 9.7 years; median, 8.0 years). One patient experienced malocclusion after surgery. However, we did not observe any recurrences during the follow-up period.
Conclusion: We conclude that the Le Fort I approach is a safe technique that permits the total resection of the JA with a low rate of postoperative complications and a low rate of recurrence.
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http://dx.doi.org/10.1016/j.amjoto.2003.12.001 | DOI Listing |
Circ Res
December 2024
Cardiovascular Research Center, Massachusetts General Hospital, Boston. (C.C., P.X., Z.Y., Y.S., E.S.L., J.D.R., M.C.H.).
Background: Preeclampsia is a hypertensive disorder of pregnancy characterized by systemic endothelial dysfunction. The pathophysiology of preeclampsia remains incompletely understood. This study used human venous endothelial cell (EC) transcriptional profiling to investigate potential novel mechanisms underlying EC dysfunction in preeclampsia.
View Article and Find Full Text PDFJ Proteome Res
December 2024
Facultad de Ciencias, Universidad de la República, Sección Genómica Funcional, Montevideo 11400, Uruguay.
Noncoding RNA 886 has emerged as a pivotal regulatory RNA with distinct functions across tissues, acting as a regulator of protein activity by directly binding to protein partners. While it is well recognized as a tumor suppressor in prostate cancer, the underlying molecular mechanisms remain elusive. To discover the principal pathways regulated by nc886 in prostate cancer, we used a transcriptomic and proteomic approach analyzing malignant DU145, LNCaP, PC3, and benign RWPE-1 prostate cell line models transiently transfected with in vitro transcribed nc886 or antisense oligonucleotides.
View Article and Find Full Text PDFCureus
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Plastic and Reconstructive Surgery, Middletown Aesthetics and Plastic Surgery, Middletown, USA.
Dog bites are one of the most common injuries in the United States, with varying presentations such as avulsion injuries and lacerations, and they range from a single bite to multiple bites in a victim. The severity of the dog bite is often the biggest factor in determining the treatment course. This report discusses the treatment of a 60-year-old male with severe facial avulsion trauma from a dog bite.
View Article and Find Full Text PDFJ Craniomaxillofac Surg
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Glasgow University Dental Hospital & School, Glasgow, UK. Electronic address:
This study was carried out to compare the stability of Le Fort I maxillary advancement between the surgery-first approach (SFA) and the orthodontics-first approach (OFA), and to evaluate the impact of the quality of postoperative occlusion on maxillary stability. In total, 26 patients (13 SFA and 13 OFA) were included in this study. Cone beam computed tomography (CBCT) scans taken at T0 (1 week before surgery), T1 (1 week after surgery), and T2 (6 months after surgery) were used for the assessment of maxillary stability.
View Article and Find Full Text PDFCase Rep Womens Health
December 2024
Department of General Gynecology and Gynecologic Oncology, Medical University of Vienna, Austria.
Anterior exenteration is a radical surgical option for treating locally advanced pelvic malignancies when alternative treatments are deemed ineffective or inappropriate. Due to its nature as an ablative treatment, interference with supportive structures of the pelvic floor can result in pelvic organ prolapse. A 70-year-old woman presented with prolapse after radical cystectomy and following two unsuccessful attempts at Le Fort colpocleisis, the second of which was further complicated by rupture of the vaginal cuff.
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