The advent of computers and electronic databases have revolutionized the way that clinical research is done. If study inclusion criteria are saved in the database, creating a study population can be accomplished by constructing an electronic query. Prospectively-entered outcome data related to a particular patient population then can be accessed and exported to a statistical software application for analysis. The senior author has more than 2 decades of experience with computer-based clinical outcome databases. In the context of his personal experience, this review offers some insights related to database design and maintenance.
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