AI Article Synopsis
- The diploid genome sequence of the fungal pathogen Candida albicans was sequenced using a whole-genome shotgun approach on strain SC5314, a clinical isolate.
- New computational methods were developed to effectively assemble the genome, confirming its heterozygous nature in alignment with existing physical mapping data.
- The study offers insights into the organism's heterozygosity and its evolutionary background, enhancing our understanding of its pathogenesis mechanisms.
Article Abstract
We present the diploid genome sequence of the fungal pathogen Candida albicans. Because C. albicans has no known haploid or homozygous form, sequencing was performed as a whole-genome shotgun of the heterozygous diploid genome in strain SC5314, a clinical isolate that is the parent of strains widely used for molecular analysis. We developed computational methods to assemble a diploid genome sequence in good agreement with available physical mapping data. We provide a whole-genome description of heterozygosity in the organism. Comparative genomic analyses provide important clues about the evolution of the species and its mechanisms of pathogenesis.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC409918 | PMC |
| http://dx.doi.org/10.1073/pnas.0401648101 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!