The authors present a case of proliferative verrucous leukoplakia (PVL) in a 78-year-old man. It was initially presented as leukoplakia on the tongue but a microscopic investigation in 1991 revealed it to be a mild epithelial dysplasia. After 5 years of follow-up, the lesion presented changes in size and location, and a recidivant behavior. In 1996, a red granular and indurated area that appeared on the tongue was found to be a microinvasive squamous cell carcinoma when microscopically investigated. After a review of the clinicopathologic behavior of this entity, the authors concluded that it was a typical PVL, whose diagnosis is difficult and retrospective, as indicated by others. The authors emphasize the importance of periodic detailed clinical and histological examination of this type of lesions in order to detect early signs of malignancy.
Download full-text PDF |
Source |
|---|
Publication Analysis
Top Keywords
Similar Publications
Genome-Wide DNA Methylation Confirms Oral Squamous Cell Carcinomas in Proliferative Verrucous Leukoplakia as a Distinct Oral Cancer Subtype: A Case-Control Study.
Cancers (Basel)
January 2025
Medicina Bucal Unit, Stomatology Department, Valencia University, 46010 Valencia, Spain.
Background/objectives: Oral cancers in patients with proliferative verrucous leukoplakia (PVL-OSCC) exhibit different clinical and prognostic outcomes from those seen in conventional oral squamous cell carcinomas (cOSSCs). The aim of the present study is to compare the genome-wide DNA methylation signatures in fresh frozen tissues between oral squamous cell carcinomas in patients with PVL and cOSCC using the Illumina Infinium MethylationEPIC BeadChip.
Methods: This case-control study was carried out at the Stomatology and Maxillofacial Surgery Department of the General University Hospital of Valencia.
The Effect of Oral Potentially Malignant Disorders (OPMD) on Dental Implants Survival-A Systematic Review.
Dent J (Basel)
January 2025
Department of Oral and Maxillofacial Surgery, University Medical Center, Johannes Gutenberg-University, 55131 Mainz, Germany.
This research is purposed to synthesize the existing evidence on implant survival rates in patients with oral potentially malignant disorders (OPMD) and assess potential risk factors associated with peri-implant disease. A comprehensive search was performed across PubMed MEDLINE, Cochrane Library, and Web of Science. This review was conducted according to the PRISMA guidelines, including studies published between 2012 and 2023.
View Article and Find Full Text PDFDNA methylation analysis from oral brushing reveals a field cancerization effect in proliferative verrucous leukoplakia.
Pathologica
December 2024
Functional and Molecular Neuroimaging Unit, Bellaria Hospital, Department of Biomedical and Neuromotor Sciences, University of Bologna, Bologna, Italy.
Objectives: The aim of the present study was to analyze the methylation status in patients who presented with an Oral Squamous Cell Carcinoma (OSCC) concomitantly with multifocal Proliferative Verrucous Leukoplakia (PVL)(PVL-OSCC).
Methods: Nine patients with OSCC and concomitant PVL lesions were selected. Two brushing samples were collected simultaneously from OSCC and PVL lesions in contralateral mucosa from each patient.
Bibliometric analysis of 100 most cited papers on oral proliferative verrucous leukoplakia.
J Oral Biol Craniofac Res
December 2024
Department of Oral Pathology and Microbiology, Dr. D.Y. Patil Dental College and Hospital, Dr. D.Y. Patil Vidyapeeth, Sant-Tukaram Nagar, Pimpri, Pune, 411018, MH, India.
Background: Bibliometric analysis of highly cited papers in a particular discipline brings forward the impactful papers published, the significant journals and the researchers in the field. These studies help in identifying research trends and research lacunae in the field, thus guiding the future research works. Oral proliferative verrucous leukoplakia (OPVL) is a challenging lesion with no uniform diagnostic criteria.
View Article and Find Full Text PDFDemographic and clinicopathological comparison among oral lichen planus, lichenoid lesions and proliferative verrucous leukoplakia: a retrospective study.
BMC Oral Health
December 2024
Dental Sciences Graduate Program. Federal University of Espirito Santo (UFES), Avenida Maruípe 1468, Maruípe, Vitória, 29040-090, ES, Brazil.
Article Synopsis
- The study focused on comparing oral lichen planus and related lesions due to their risk of becoming cancerous and the need to differentiate them from similar conditions.
- Researchers conducted a survey among patients to collect sociodemographic and clinical data, analyzing this information using statistical tests.
- The findings revealed distinct characteristics for each type of lesion, with lichen planus showing reticular patterns and the buccal mucosa being the most affected area, while proliferative verrucous leukoplakia was linked with significant epithelial dysplasia.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!