Heart induction: embryology to cardiomyocyte regeneration.

Trends Cardiovasc Med

Ann Foley and Mark Mercola are at the Stem Cell and Regeneration Program, The Burnham Institute, La Jolla, California, USA.

Published: April 2004

Developmental biologists have uncovered many of the signaling proteins that are required to recruit early embryonic cells to the myocardial lineage. A detailed understanding of their function should provide insights into the difficult task of inducing embryonic stem cells to develop cardiomyocyte precursors for cell-based therapies. These proteins may also prove to be useful to stimulate progenitor cells to differentiate into cardiomyocytes within the damaged heart.

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http://dx.doi.org/10.1016/j.tcm.2004.01.003DOI Listing

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