AI Article Synopsis
- A new system called the dynamic-culture force monitor (D-CFM) has been created to study how cells respond to mechanical forces.
- This system improves on previous technology by measuring forces in cell-populated collagen gels using a cantilever beam paired with semiconductor strain gauges, allowing for precise control of motion through LabVIEW software.
- Early tests demonstrate that D-CFM can differentiate force patterns caused by various motion waveforms, which will help researchers understand how mechanical loading affects cells and their interactions with the extracellular matrix.
Article Abstract
To study mechanobiological responses of cells, a dynamic-culture force monitor (D-CFM) system has been developed. The D-CFM extends our previous work to measure contractile forces of a cell-populated collagen gel (CPCG) using a cantilever beam with semiconductor strain gauges. Linear actuators are used in the system and are computer controlled using a LabVIEW interface to independently apply precise motion waveforms to multiple CPCGs. The feasibility tests showed that the new system can detect the differences in force patterns resulting from different motion waveforms imparted to the CPCG. This new system will facilitate the study of the effects of dynamic mechanical loading on cells, remodeling of extracellular matrix, and cell-matrix interactions in vitro.
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| http://dx.doi.org/10.1016/j.medengphy.2003.10.004 | DOI Listing |
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