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A case of trichoblastic carcinoma admixed with histological features of trichoblastoma, trichoepithelioma, and basal cell carcinoma.
Malays J Pathol
December 2024
Kawasaki Medical School, Department of Pathology, Okayama, Japan.
Trichoblastic carcinoma, trichoblastoma, trichoepithelioma, and basal cell carcinoma are histologically characterised by basaloid cell proliferation. In this report, we describe the case of a 76-year-old man who presented with trichoblastic carcinoma admixed with histological features of trichoblastoma, trichoepithelioma, and basal cell carcinoma. These tumours may not be situated separately but must be related to each other in terms of tumorigenesis.
View Article and Find Full Text PDFA Dark Horse: Colonial System of Integration in Ctenostome Bryozoans (Gymnolaemata: Ctenostomata).
J Morphol
January 2025
Department of Invertebrate Zoology, Saint Petersburg State University, Saint Petersburg, Russian Federation.
The colonial system of integration (CSI) provides intracolonial nutrient supply in many gymnolaemate bryozoans. In Ctenostomata, its presence is known for species with stolonal colonies, for example, vesicularioideans, but its structure is almost unexplored. The CSI is thought to be absent in alcyonidioideans and other ctenostomes.
View Article and Find Full Text PDFExpression of Yes-associated protein in endothelial cells of human corneas before and after storage in organ culture.
Sci Rep
December 2024
Laboratory of Biology, Engineering, and Imaging for Ophthalmology, BiiO, Faculty of Medicine, University of Jean Monnet, 10 rue de la Marandière, 42270, Saint-Priest en Jarez, France.
The cornea, the anterior meniscus-shaped transparent and refractive structure of the eyeball, is the first mechanical barrier of the eye. Its functionality heavily relies on the health of its endothelium, its most posterior layer. The treatment of corneal endothelial cells (CECs) deficiency is allogeneic corneal graft using stored donor corneas.
View Article and Find Full Text PDFTFEB triggers a matrix degradation and invasion program in triple-negative breast cancer cells upon mTORC1 repression.
Dev Cell
December 2024
Institut Curie, CNRS UMR 144, PSL University, 75005 Paris, France. Electronic address:
The phosphatidylinositol 3-kinase (PI3K)/AKT/mammalian target of rapamycin (mTOR) pathway is frequently hyperactivated in triple-negative breast cancers (TNBCs) associated with poor prognosis and is a therapeutic target in breast cancer management. Here, we describe the effects of repression of mTOR-containing complex 1 (mTORC1) through knockdown of several key mTORC1 components or with mTOR inhibitors used in cancer therapy. mTORC1 repression results in an ∼10-fold increase in extracellular matrix proteolytic degradation.
View Article and Find Full Text PDFAnalysis of Immunosuppression and Antioxidant Damage in Diploid and Triploid Crucian Carp () Induced by Saline-Alkaline Environmental Stress: From Metabolomic Insight.
Metabolites
December 2024
Laboratory of Quality & Safety Risk Assessment for Aquatic Products, Heilongjiang River Fisheries Research Institute, Chinese Academy of Fishery Sciences, Ministry of Agriculture and Rural Areas, Harbin 150070, China.
The salinization of the water environment worldwide is increasing, which has brought great challenges to the sustainability of fish farming of aquatic animals. Three NaHCO concentration groups (0 mmol/L, 20 mmol/L, and 60 mmol/L) were set up in this study to investigate growth and metabolic differences between diploid and triploid crucian carp under saline-alkaline stresses. This study utilized UPLC-QTOF/MS metabolomics to analyze significant metabolites and metabolic pathways in the serum of diploid and triploid crucian carp, exposing them to different NaHCO concentrations in saline-alkaline habitats, elucidating the mechanism of their metabolic differences.
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