Oxidative, chemical cleavage of the C-P bond in 1-amino-1-(3,4-dihydroxyphenyl)methylphosphonic acid upon the action of NaIO(4) have been the subject of the NMR, EPR and UV-Vis investigations in acidic and basic conditions.
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http://dx.doi.org/10.1039/b401633e | DOI Listing |
Genes (Basel)
December 2024
Department of Pediatric Dentistry & DRI, School of Dentistry, Seoul National University, Seoul 03080, Republic of Korea.
Background/objectives: The ectodysplasin A () gene, a member of the tumor necrosis factor ligand superfamily, is involved in the early epithelial-mesenchymal interaction that regulates ectoderm-derived appendage formation. Numerous studies have shown that mutations in the gene can cause X-linked ectodermal dysplasia (ED) and non-syndromic oligodontia (NSO). Accordingly, this study aimed to identify the causative genetic mutations of the gene.
View Article and Find Full Text PDFACS Pharmacol Transl Sci
January 2025
Fraunhofer Institute for Translational Medicine and Pharmacology ITMP, Discovery Research ScreeningPort, Schnackenburgallee 114, 22525 Hamburg, Germany.
The SARS-CoV-2 papain-like protease PLpro has multiple roles in the viral replication cycle, related to both its polypeptide cleavage function and its ability to antagonize the host immune response. Targeting the PLpro function is recognized as a promising mechanism to modulate viral replication, while supporting host immune responses. However, the development of PLpro-specific inhibitors remains challenging.
View Article and Find Full Text PDFInorg Chem
December 2024
Department of Chemistry, Shahid Beheshti University, Tehran 19839-69411, Iran.
This study investigates possible pathways arising from the reaction of anionic K[Pt(C^N)(-MeCH)(CN)] complexes, C^N = 2-phenylpyridinate (ppy) and 7,8-benzo[h]quinolate (bzq), with trifluoroacetic acid (TFA), which has been employed in both experimental and computational approaches. Experimental studies clarify that the products of the protonolysis reaction can vary in the K[Pt(C^N)(-MeCH)(CN)] complex depending on the type of the cyclometalated ligand. In the cyclometalated complex with ppy, only one product was observed, resulting from the cleavage of the Pt-C bond of the cyclometalated ligand.
View Article and Find Full Text PDFInorg Chem
December 2024
Centro de Química Estrutural, Institute of Molecular Sciences, Department of Chemical Engineering Instituto Superior Técnico, Universidade de Lisboa, Av. Rovisco Pais 1, 1000-049 Lisboa, Portugal.
The reactivity of ruthenium hydride complexes supported by 2-((di--butylphosphaneyl)methyl)pyridine, and 2-(di--butylphosphaneyl)pyridine, , was explored. The reaction of {Ru(COD)Cl} with in the presence of base and 10 bar of H gave the expected complex [Ru(L1)(H)Cl], , while the same reaction with gave [Ru(L2)(P(H)Bu)(H)Cl], , that results from the cleavage of a C-P bond. We were able to establish that under the reaction conditions the first species formed is [Ru(L2)(H)Cl], , and that this species decomposes to give complex and is in equilibrium with [Ru(L)Cl], .
View Article and Find Full Text PDFACS Infect Dis
December 2024
Department for Infectious Diseases, Division of Enteropathogenic Bacteria and Legionella (FG11), National Reference Centre for Salmonella and other Enteric Bacterial Pathogens, Robert Koch Institute, 38855 Wernigerode, Germany.
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