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Application of Three Types of Scaffolds in Pulp Regeneration for Permanent Mature Teeth with Periapical Lesions: A Randomized Controlled Trial.
Eur Endod J
December 2024
Department of Pediatric Dentistry, Damascus University, Faculty of Dentistry, Damascus, Syria.
Objective: This study aimed to evaluate pulp regeneration by comparing the application of native chitosan-based scaffolds with enzymatically modified chitosan-based scaffolds in mature teeth with apical lesions, using clinical and radiographic assessments.
Methods: The eligibility criteria for this study were participants aged between 15-45 years, free from systemic diseases and with necrotic mature single-rooted teeth with periapical lesions. The teeth were equally and randomly allocated into three groups (1: 1: 1 allocation): Group A received treatment with a Blood Clot (BC) scaffold; Group B with a combination of Native Chitosan and Blood Clot (NCS+BC) scaffold; and Group C with Enzymatically-Modified Chitosan and Blood Clot (EMCS+BC) scaffold.
Comparative Effectiveness of Regenerative Endodontic Treatment Versus Apexification for Necrotic Immature Permanent Teeth With or Without Apical Periodontitis: An Umbrella Review.
Dent Traumatol
December 2024
Division of Pediatric and Preventive Dentistry, Centre for Dental Education and Research, All India Institute of Medical Sciences, New Delhi, India.
Background/aim: The evidence related to the superiority of the recommended treatment protocols for necrotic immature permanent teeth is unclear. We aimed to compare the clinical, radiographic, and overall success rates of apexification and regenerative endodontic treatment (RET), assess the methodological quality, and assess the strength of evidence for outcomes.
Methods: A search was performed in PubMed, Scopus, LILACS, EMBASE, Web of Science, and the Cochrane Library.
Evaluation of Effect of Laser in Root Canal Disinfection in Pulp Regenerative Therapy: A Systematic Review.
Photobiomodul Photomed Laser Surg
December 2024
Department of Conservative Dentistry & Endodontics, Government Dental College and Research Institute, Fort, Bangalore, India.
The evaluation of the effect of laser in disinfection of root canal in pulp regenerative therapy, if found effective laser can be used for root canal disinfection in cases of regenerative endodontic therapy. This study includes a systematic review addressing the question of whether laser is effective in root canal treatment in regenerative endodontic therapy. Randomized controlled trials (RCTs), case series, and animal studies evaluating the effect of laser-assisted endodontic irrigation in pulp regenerative therapy were included.
View Article and Find Full Text PDFA novel AI model for detecting periapical lesion on CBCT: CBCT-SAM.
J Dent
February 2025
Department of Restorative Dental Sciences, Faculty of Dentistry, The University of Hong Kong, Hong Kong SAR, PR China. Electronic address:
Objectives: Periapical lesions are not always evident on radiographic scans. Sometimes, asymptomatic or initial periapical lesions on cone-beam computed tomography (CBCT) could be missed by inexperienced dentists, especially when the scan has a large field of view and is not for endodontic treatment purposes. Previously, numerous algorithms have been introduced to assist radiographic assessment and diagnosis in the field of endodontics.
View Article and Find Full Text PDFEndodontic treatment modifies circulatory inflammatory mediator levels: A systematic review with meta-analysis.
Int Endod J
February 2025
Division of Restorative Dentistry & Periodontology, Dublin Dental University Hospital, Trinity College Dublin, Dublin, Ireland.
Background: There is limited and conflicting data on the reduction of circulatory inflammatory mediators in patients with apical periodontitis (AP) following endodontic treatment.
Objective: To answer the following research question: in adult healthy patients with AP [Population (P)], is there a difference before [Comparator (C)] and after various endodontic treatments (nonsurgical, surgical or retreatment) [Intervention (I)] on systemic levels of inflammatory biomarkers [Outcome (O)] in the follow-up period [Time (T)]?
Methods: An electronic literature search was conducted in the databases Scopus, PubMed, Clarivate Analytics' Web of Science, Cochrane Database of Systematic Reviews and Grey literature from inception to July 2024 with no language restrictions. Observational studies examining changes in serum levels of inflammatory mediators were included.
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