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Facility-Level Differences in Antipsychotic Drug Use: Impact on Quality Outcomes for Nursing Home Residents.
Med Care
December 2024
Department of Health Care Policy, Harvard Medical School, Boston, MA.
Objective: To quantify quality of care following an admission to a nursing home with low or high antipsychotic drug use.
Background: Misuse of antipsychotics in U.S.
Plausible mechanism of drug resistance and side-effects of COVID-19 therapeutics: a bottleneck for its eradication.
Daru
December 2024
Laboratory for Structural Biology of Membrane Proteins, Dr. B.R. Ambedkar Center for Biomedical Research, University of Delhi, Delhi, 110007, India.
Background: COVID-19 pandemic has turned our world upside down by meddling with our normal lives. While there is no definitive drug against SARS-CoV-2, antiviral drugs that are already in the market, are being repurposed against it, could now complete long-term as well as all age-specific investigations, and they are successful in saving millions of lives. Nevertheless, side-effects are emergingly seen in the patients undergoing treatment, and ineffectiveness is increasingly found due to the emerging notorious variants of the virus.
View Article and Find Full Text PDFSignificant reduction of the culturing time required for bacterial identification and antibiotic susceptibility determination by infrared spectroscopy.
Anal Methods
June 2024
Department of Physics, SCE - Shamoon College of Engineering, Beer-Sheva 84100, Israel.
Rapid testing of bacteria for antibiotic susceptibility is essential for effective treatment and curbing the emergence of multidrug-resistant bacteria. The misuse of antibiotics, coupled with the time-consuming classical testing methods, intensifies the threat of antibiotic resistance, a major global health concern. In this study, employing infrared spectroscopy-based machine learning techniques, we significantly shortened the time required for susceptibility testing to 10 hours, a significant improvement from the 24 hours in our previous studies as well as the conventional methods that typically take at least 48 hours.
View Article and Find Full Text PDFAcute nicotine administration reduces the efficacy of punishment in curbing remifentanil consumption in a seeking-taking chain schedule of reinforcement.
Psychopharmacology (Berl)
October 2024
Program in Behavioral Neuroscience, Department of Psychology, State University of New York, University at Buffalo, 204 Park Hall, Buffalo, NY, 14260, USA.
Article Synopsis
- Nicotine dependence is closely linked with opioid use disorders (OUDs), and using both nicotine and opioids simultaneously can lead to more effective treatment outcomes than treating OUDs alone.
- The study explored how nicotine influences the self-administration of remifentanil (a synthetic opioid) in rats, focusing on their behavior under both rewarded and punished conditions.
- Results showed that nicotine increased the rats' consumption of remifentanil and made them less responsive to punishment, suggesting that nicotine not only boosts the desire to use opioids but also makes it harder for individuals to resist such cravings.
A medical big data access control model based on smart contracts and risk in the blockchain environment.
Front Public Health
April 2024
Faculty of Information Engineering and Automation, Kunming University of Science and Technology, Kunming, China.
The rapid development of the Hospital Information System has significantly enhanced the convenience of medical research and the management of medical information. However, the internal misuse and privacy leakage of medical big data are critical issues that need to be addressed in the process of medical research and information management. Access control serves as a method to prevent data misuse and privacy leakage.
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