Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1002/anie.200353366 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Secondary Alkylation of Arenes via the Borono-Catellani Strategy.
J Am Chem Soc
January 2025
Engineering Research Center of Organosilicon Compounds & Materials (Ministry of Education), Hubei Key Lab on Organic and Polymeric OptoElectronic Materials, College of Chemistry and Molecular Sciences, and TaiKang Center for Life and Medical Sciences, Wuhan University, Wuhan 430072, China.
A modular platform technology for the synthesis of α-aryl carbonyl derivatives via Borono-Catellani-type secondary alkylation of arenes is presented. This practical method features a broad substrate scope regarding aryl boronic acid catechol esters, secondary alkyl bromides, and diversified terminating reagents (e.g.
View Article and Find Full Text PDFEnantioselective Synthesis of Nonfused Eight-Membered O-Heterocycles by Sequential Catalysis.
Org Lett
January 2025
Catalytic Hydrogenation Research Center, State Key Laboratory Breeding Base of Green Chemistry-Synthesis Technology, Key Laboratory of Green Pesticides and Cleaner Production Technology of Zhejiang Province, Zhejiang University of Technology, Hangzhou 310014, P. R. China.
This work describes a chiral bifunctional squaramide/DBU sequential catalytic strategy for the enantioselective synthesis of nonfused chiral eight-membered O-heterocycles through the asymmetric addition of ynones to β,γ-unsaturated α-ketoesters followed by the regio- and diastereoselective cyclization of the adduct intermediates. Mechanistic experiments revealed that an isomerization process should be involved in the ring formation step, and the origin of the high regioselectivity and diastereoselectivity has also been elucidated by the DFT calculations.
View Article and Find Full Text PDFIntramolecular Anti-Markovnikov Alkene Hydroaminative Cyclization to -2,3-Disubstituted Piperidines.
Org Lett
December 2024
Shanghai Key Laboratory of Green Chemistry and Chemical Processes, State Key Laboratory of Petroleum Molecular & Process Engineering, School of Chemistry and Molecular Engineering, East China Normal University, Shanghai 200062, China.
Multisubstituted piperidines are prevalent units in pharmaceuticals. Herein, a photodriven anti-Markovnikov hydroaminative cyclization of a ()/()-isomeric mixture of trisubstituted alkenes using the lactate-derived -symmetric arylthiol catalyst was developed for the synthesis of -2,3-disubstituted piperidines and azepane in high diastereoselectivity and good yields. The origin of diastereoselectivity and the observed different hydroamination rate of alkene with different configurations were elucidated by the experimental and computational investigation.
View Article and Find Full Text PDFGold/HNTf-Cocatalyzed Asymmetric Annulation of Diazo-Alkynes: Divergent Construction of Atropisomeric Biaryls and Arylquinones.
J Am Chem Soc
December 2024
College of Chemistry & Materials Engineering, Wenzhou University, Wenzhou 325035, China.
Article Synopsis
- The paper discusses the challenges in creating axially chiral compounds using gold(I) catalysis, particularly in asymmetric synthesis, which has seen limited progress.
- A new method is introduced that utilizes gold/HNTf cocatalysis for asymmetric diazo-alkyne annulation, successfully producing chiral biaryls and arylquinones with high yields and enantioselectivity.
- The study also extends this methodology to synthesize seven-membered-ring atropisomers and includes insights about the mechanism and role of HNTf through computational and experimental analysis.
Stereoselective Fe-Catalyzed Decoupled Cross-Couplings: Chiral Vinyl Oxazolidinones as Effective Radical Lynchpins for Diastereoselective C(sp)-C(sp) Bond Formation.
ACS Catal
September 2024
Department of Chemistry, Texas A&M University, College Station, Texas 77843, United States.
Modular, catalytic, and stereoselective methods for the dicarbofunctionalization of alkenes can streamline the synthesis of chiral active pharmaceutical ingredients (APIs) and agrochemicals. However, despite the inherent attractive properties of iron as catalysts for practical pharmaceutical synthesis (i.e.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!