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Role of organophosphorus pesticides in facilitating plasmid-mediated conjugative transfer: Efficiency and mechanisms.
J Hazard Mater
January 2025
Faculty of Environmental Science & Engineering, Kunming University of Science and Technology, Kunming 650500, China. Electronic address:
Non-antibiotic conditions, including organophosphorus pesticides (OPPs), have been implicated in the horizontal gene transfer (HGT) of antibiotic resistance genes (ARGs) to varying degrees. While most studies focus on the toxicity of OPPs to humans and animals, their roles in ARG dissemination remain largely unexplored. In this study, we investigate the effects and involved molecular mechanisms of environmentally relevant concentrations of malathion and dimethoate, two representative OPPs, on plasmid-mediated conjugal transfer.
View Article and Find Full Text PDFFrom cell to organ: Exploring the toxicological correlation of organophosphorus compounds in living system.
Toxicology
January 2025
Department of Medical Elementology and Toxicology, Jamia Hamdard, Delhi 110062, India. Electronic address:
Malathion is an organophosphate compound widely used as an insecticide in the agriculture sector and is toxic to humans and other mammals. Although several studies have been conducted at different levels in different animal models. But there is no work has been conducted on the toxicological correlation from cellular to behavioral level in surviving species model.
View Article and Find Full Text PDFThe Danjiangkou Reservoir is the largest artificial freshwater lake in Asia. This study investigated the spatiotemporal distribution of pesticides and polycyclic aromatic hydrocarbons (PAHs) in the Danjiangkou Reservoir to assess the ecological and human health risks associated with these pollutants. Twenty-three sampling sites in the Danjiangkou Reservoir each collected 23 surface water samples and 23 sediment samples.
View Article and Find Full Text PDFInsights into organophosphorus insecticide malathion induced reproductive toxicity and intergenerational effect in zebrafish (Danio rerio).
Sci Total Environ
January 2025
Beijing Advanced Innovation Centre for Food Nutrition and Human Health, Department of Applied Chemistry, China Agricultural University, No.2 West Yuanmingyuan Road, Beijing 100193, PR China. Electronic address:
The reproductive and transgenerational effects of malathion, a widely utilized low-toxicity organophosphorus insecticide, were explored using zebrafish as model animal. Adult zebrafish (F0) were exposed to malathion at 0.1-1.
View Article and Find Full Text PDFEsterase-2 mutant-based nanostructured amperometric biosensors for the selective determination of paraoxon (Neurotoxin).
Anal Biochem
March 2025
Biosensors Research Lab, Zewail City of Science and Technology, 6th October City, Giza, 12578, Egypt; Applied Organic Chemistry Department, National Research Centre (NRC), Dokki, Giza, 2622, Egypt. Electronic address:
Organophosphate pesticides (OPs) are causing non-selective inhibition in enzymatic bioreceptors, thus the enzymatic-inhibition-based traditional assays are not suitable for their specific detection in food and environmental samples. Accordingly, a selective nanostructured electrochemical biosensing system was designed using six mutants of the esterase-2 (EST2 protein) enzymes from A. acidocaldarius to be exploited as targeting bio-receptors for the specific detection of OPs.
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