A (82)Rb infusion system is described with two important features for imaging with 3D positron emission tomography. First, a generator bypass line is added to flush the patient infusion line at the end of an elution. Second, feedback control is implemented to permit 'slow-bolus' constant-activity elutions. A model for the activity eluted from a (82)Sr/(82)Rb generator based on a volume-activity empirical relationship, is used as the basis for performing simulations to demonstrate the efficacy of varying the flow rate through the generator to achieve desired eluted (82)Rb activity rate profiles. A (82)Rb infusion system was constructed to verify the accuracy of the simulations. The system can deliver accurate constant-activity elutions from 10% to 70% of the total generator activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.apradiso.2004.02.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Pulmonary blood volume measured by Rb-PET in patients with chronic obstructive pulmonary disease: a retrospective cohort study.
J Appl Physiol (1985)
May 2024
Centre for Physical Activity Research, Copenhagen University Hospital-Rigshospitalet, Copenhagen, Denmark.
In patients with chronic obstructive pulmonary disease (COPD), pulmonary vascular dysfunction and destruction are observable before the onset of detectable emphysema, but it is unknown whether this is associated with central hypovolemia. We investigated if patients with COPD have reduced pulmonary blood volume (PBV) evaluated by Rb-positron emission tomography (PET) at rest and during adenosine-induced hyperemia. This single-center retrospective cohort study assessed 6,301 Rb-PET myocardial perfusion imaging (MPI) examinations performed over a 6-yr period.
View Article and Find Full Text PDFReliability of rubidium-82 PET/CT for renal perfusion determination in healthy subjects.
BMC Nephrol
November 2022
University Clinic in Nephrology and Hypertension, Department of Medicine, Gødstrup Hospital and Aarhus University, Herning, Denmark.
Background: Changes in renal perfusion may play a pathophysiological role in hypertension and kidney disease, however to date, no method for renal blood flow (RBF) determination in humans has been implemented in clinical practice. In a previous study, we demonstrated that estimation of renal perfusion based on a single positron emission tomography/computed tomography (PET/CT) scan with Rubidium-82 (Rb) is feasible and found an approximate 5% intra-assay coefficient of variation for both kidneys, indicative of a precise method.This study's aim was to determine the day-to day variation of Rb PET/CT and to test the method's ability to detect increased RBF induced by infusion of amino acids.
View Article and Find Full Text PDFPredictive Model for Rb Generator Bolus Times as a Function of Generator Lifetime.
J Nucl Med Technol
March 2022
Department of Clinical Research Operations, City of Hope, Duarte, California.
Rb cardiac PET is largely used to study myocardial perfusion with function and to calculate myocardial blood flow (MBF) and coronary flow reserve or myocardial flow reserve. Although the dosing activity of Rb is determined by the patient weight, the infusion volume and activity concentration varies with the age of the Rb generator. We sought to predict the needed bolus volume of Rb to help evaluate the accuracy of MBF findings.
View Article and Find Full Text PDFBlood-brain barrier permeability in Parkinson's disease patients with and without dyskinesia.
J Neurol
June 2021
Center for Neurosciences, The Feinstein Institutes for Medical Research, 350 Community Drive, Manhasset, NY, 11030, USA.
Objective: Recent studies on a rodent model of Parkinson's disease (PD) have raised the possibility of increased blood-brain barrier (BBB) permeability, demonstrated by histology, autoradiography, and positron emission tomography (PET). However, in human PD patients, in vivo evidence of increased BBB permeability is lacking. We examined the hypothesis that levodopa treatment increases BBB permeability in human subjects with PD, particularly in those with levodopa-induced dyskinesia (LID).
View Article and Find Full Text PDFStimulation of the hepatic arterial buffer response using exogenous adenosine: hepatic rest/stress perfusion imaging.
Eur Radiol
November 2020
Department of Nuclear Medicine, King's College Hospital NHS Foundation Trust, Denmark Hill, Brixton, London, SE5 9RS, UK.
Objectives: The hepatic arterial buffer response is a mechanism mediated by adenosine whereby hepatic arterial perfusion (HAP) increases when portal flow decreases, and is implicated in liver disease. The first study aim was to measure HAP in patients undergoing myocardial perfusion imaging (MPI), thus developing hepatic arterial rest/stress perfusion imaging (HAPI). The second aim was to compare adenosine-induced changes in splenic perfusion (SP) and HAP with corresponding changes in myocardial blood flow (MBF).
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!