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Seltorexant for major depressive disorder.
Expert Opin Emerg Drugs
January 2025
Department of Psychiatry, University of Toronto, Toronto, ON, Canada.
Introduction: Preclinical and clinical pharmacologic evidence indicate that orexin systems are relevant to sleep-wake cycle regulation and dimensions of reward and cognition, providing the basis to hypothesizing that they may be effective as therapeutics in mental disorders. Due to the limited efficacy and tolerability profiles of existing treatments for Major Depressive Disorder (MDD), investigational compounds in novel treatment classes are needed; seltorexant, an orexin receptor antagonist, is a potential new treatment currently under investigation.
Areas Covered: Mechanisms implicated in MDD, including reward and sleep are first overviewed.
Health impacts of a remotely delivered prolonged nightly fasting intervention in stressed adults with memory decline and obesity: A nationwide randomized controlled pilot trial.
J Clin Transl Sci
November 2024
College of Health Solutions, Arizona State University, Phoenix, AZ, USA.
Objective/goals: Cognitive decline is intricately linked to various factors such as obesity, stress, poor sleep, and circadian rhythm misalignment, which are interrelated in their impact on cognitive health. Irregular food-intake timing further compounds these issues. The practice of prolonged nightly fasting (PNF) may help synchronize food intake with circadian rhythms, potentially mitigating adverse effects of cognitive decline and associated factors.
View Article and Find Full Text PDFUnderstanding the Medical Education Experiences of Low-Income Students Through a Maslow's Hierarchy of Needs Lens: An Exploratory Qualitative Study.
J Gen Intern Med
January 2025
MD/PhD Program, Yale School of Medicine, New Haven, CT, USA.
Background: Diversity in the physician workforce is critical for quality patient care. Students from low-income backgrounds represent an increasing proportion of medical school matriculants, yet little research has addressed their medical school experiences.
Objective: To explore the medical school experiences of students from low-income backgrounds using a modified version of Maslow's Hierarchy of Needs (physiologic, safety, love/belonging, esteem, and self-actualization) as a theoretical framework.
Investigation of the Content Offered to the Public Regarding Noise Pollution in Online News.
Noise Health
January 2025
Department of Public Health, William Paterson University, Wayne, New Jersey, USA.
Background/objectives: Noise remains an under-discussed type of environmental pollutant, which exerts a wide range of adverse health effects, both auditory and non-auditory. Ensuring that the public has ready access to useful health information online about noise exposure is important. In this regard, evaluating the content of public news articles regarding noise pollution is vital.
View Article and Find Full Text PDFExperiences of fasting during Ramadan in British Muslims: Psychological, social and health behaviours.
PLoS One
January 2025
Department of Psychology, University of Bradford, Bradford, United Kingdom.
Ramadan is a month-long religious festival observed by Muslim worldwide, characterised by intermittent fasting. This qualitative study addressed the need to understand how fasting is experienced by Muslims residing in Western cultures, aiming to inform policies that create a more supportive environment. Practicing Muslims, both men and women, were recruited in the North of England in the United Kingdom (UK).
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