The HIV protease inhibitor ABT-378 (lopinavir) has a six-member cyclic urea in the P-2 position. A series of analogues in which the six-member cyclic urea is replaced by various heterocycles was synthesized and the structure-activity relationships explored.
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| http://dx.doi.org/10.1016/j.bmcl.2004.02.089 | DOI Listing |
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