AI Article Synopsis
- A series of simple aromatic compounds with propenone structures were created to find safer anti-inflammatory agents.
- The compounds were tested for their ability to inhibit both COX and 5-LOX enzymes.
- Out of 17 compounds, most demonstrated significant inhibitory effects, with compound C(15) standing out as the most effective.
Article Abstract
For the development of safer anti-inflammatory agents, simple aromatic compounds containing propenone moiety were prepared and evaluated for their dual COX/5-LOX inhibitory activities. Among the 17 prepared compounds, most of the compounds exhibited considerable COX/5-LOX inhibitory activities. Especially compound C(15) showed the most significant dual COX/5-LOX inhibitory activity.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2004.02.099 | DOI Listing |
Publication Analysis
Top Keywords
cox/5-lox inhibitory
16
dual cox/5-lox
12
inhibitory activities
12
simple aromatic
8
aromatic compounds
8
compounds propenone
8
propenone moiety
8
compounds
4
moiety considerable
4
considerable dual
4
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!