Exchange of the ethylene tether in a series of pyridopyrimidine-based MexAB-OprM specific efflux pump inhibitors to an amide bond stabilized the olefin of the acrylic acid moiety, preventing facile photoisomerization to the Z-isomer. Furthermore, the activity was drastically improved in the amide tether variants, providing extremely potent acrylic acid and vinyl tetrazole analogues.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1016/j.bmcl.2004.03.007 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Cinnamic acid conjugated with triazole acetamides as anti-Alzheimer and anti-melanogenesis candidates: an in vitro and in silico study.
Sci Rep
January 2025
Stem Cells Technology Research Center, Shiraz University of Medical Sciences, Shiraz, Iran.
In this study, new cinnamic acid linked to triazole acetamide derivatives was synthesized and evaluated for anti-Alzheimer and anti-melanogenesis activities. The structural elucidation of all analogs was performed using different analytical techniques, including H-NMR, C-NMR, mass spectrometry, and IR spectroscopy. The synthesized compounds were assessed in vitro for their inhibitory activities against acetylcholinesterase (AChE), butyrylcholinesterase (BChE), and tyrosinase enzymes.
View Article and Find Full Text PDFHydrogel Electrolyte-Mediated In Situ Zn-Anode Modification and the Ru-RuO/NGr-Coated Cathode for High-Performance Solid-State Rechargeable Zn-Air Batteries.
ACS Appl Mater Interfaces
January 2025
Physical & Materials Chemistry Division, CSIR-National Chemical Laboratory, Pune, Maharashtra 411008, India.
This work aims to deal with the challenges associated with designing complementary bifunctional electrocatalysts and a separator/membrane that enables rechargeable zinc-air batteries (RZABs) with nearly solid-state operability. This solid-state RZAB was accomplished by integrating a bifunctional electrocatalyst based on Ru-RuO interface nanoparticles supported on nitrogen-doped (N-doped) graphene (Ru-RuO/NGr) and a dual-doped poly(acrylic acid) hydrogel (d-PAA) electrolyte soaked in KOH with sodium stannate additive. The catalyst shows enhanced activity and stability toward the two oxygen reactions, i.
View Article and Find Full Text PDFStructurally Transformable and Reconfigurable Hydrogel-Based Mechanical Metamaterials and Their Application in Biomedical Stents.
ACS Appl Mater Interfaces
January 2025
Institute of Materials Research and Engineering (IMRE), Agency for Science, Technology and Research (A*STAR), 2 Fusionopolis Way, Innovis #08-03, Singapore 138634, Republic of Singapore.
Mechanical metamaterials exhibit several unusual mechanical properties, such as a negative Poisson's ratio, which impart additional capabilities to materials. Recently, hydrogels have emerged as exceptional candidates for fabricating mechanical metamaterials that offer enhanced functionality and expanded applications due to their unique responsive characteristics. However, the adaptability of these metamaterials remains constrained and underutilized, as they lack integration of the hydrogels' soft and responsive characteristics with the metamaterial design.
View Article and Find Full Text PDFMicrogel-Guided MXene Assembly for High-Performance, Low-Solid Content Conductive Inks.
ACS Appl Mater Interfaces
January 2025
Department of Chemical Engineering, University of South Carolina, Columbia, South Carolina 29208, United States.
Rapid evolution of smart devices necessitates high-performance, lightweight materials for effective electromagnetic interference (EMI) shielding. TiCT MXene nanosheets are promising for such applications, yet the high solid content typically required for 3D-printable MXene inks limits their scalability and cost efficiency. In this study, we present an MXene-based ink with an ultralow solid content (0.
View Article and Find Full Text PDFSkin-Mountable Thermo-responsive Structured Hydrogel for Optical and Adhesion Coupled Functional Sensing.
Small
January 2025
State Key Laboratory of Solid Lubrication, Lanzhou Institute of Chemical Physics, Chinese Academy of Sciences, Lanzhou, 730000, China.
Smart hydrogel sensors with intrinsic responsiveness, such as pH, temperature, humidity, and other external stimuli, possess broad applications in innumerable fields such as biomedical diagnosis, environmental monitoring, and wearable electronics. However, it remains a great challenge to develop wearable structural hydrogels that possess simultaneously body temperature-responsive, adhesion-adaptable, and transparency-tunable. Herein, an innovative skin-mountable thermo-responsive hydrogel is fabricated, which endows tunable optical properties and switchable adhesion properties at different temperatures.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!