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Oxidative Stress Monitoring Platform: A Longitudinal In vitro Multinuclear (H/F) MR Spectroscopic Study.
Cell Biochem Biophys
December 2024
Department of Neurosurgery, University of Pittsburgh School of Medicine, Pittsburgh, PA, USA.
Glutathione (GSH) is a master antioxidant that counters oxidative stress. Clinical studies have confirmed significant depletion of GSH in the hippocampus and the substantia nigra as an early diagnostic biomarker for Alzheimer's disease (AD) and Parkinson disease (PD), respectively. External agents like anesthetics (inhaled and intravenous) have a different impact on GSH.
View Article and Find Full Text PDFA Case Report of Successful Off-Label Neuromodulation for Concurrent Refractory Sacroiliac Pain and Phantom Limb in a Hip Disarticulation Patient.
A A Pract
October 2024
Department of Neurosurgery, McLaren Bay Region Medical Center, Bay City, MI.
Hip disarticulation is a morbid procedure for those whose bony or soft tissues are unable to be salvaged. It involves extensive resection, and the patient featured in this report expressed mechanical pain from their sacroiliac joint (SIJ) as well as phantom limb pain (PLP). Spinal cord stimulation is known to assist with neuropathic pain syndromes, and SIJ fusion is effective in these cases of multifactorial pain.
View Article and Find Full Text PDFLow-cost phantom for ultrasound-guided popliteal sciatic nerve block.
Reg Anesth Pain Med
December 2024
Anesthesiology and Intensive Care, Charles Nicolle Hospital, Tunis, Tunisia.
Coiling of echogenic perineural catheters with integral stylet: A proof-of-concept randomized control trial in a sciatic nerve block simulator and a pilot study in orthopaedic-trauma patients.
F1000Res
December 2024
Department of Anaesthesiology, University of Toledo College of Medicine and Life Sciences, Toledo, Ohio, 43614, USA.
Backround/objectives: We investigated a technique that facilitates the coiling of a regular straight catheter (with integral stylet) behind the sciatic nerve in an ultrasound (US) regional anaesthesia simulator, and then applied our findings to a series of orthopedic-trauma patients.
Methods: We conducted a randomized study of two methods of perineural catheter advancement in a sciatic nerve block Blue Phantom simulator. Two groups of twenty catheters each (method A and method B) were evaluated under real-time ultrasound imaging.
Background: Dorsal root ganglion stimulation (DRGS) is an established method for treating persistent and severe pain conditions. However, performing DRGS has significant challenges. Current DRGS systems are expensive, hindering accessibility for many patients and health care systems.
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