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Unexpected presentation: metastatic adenoid cystic carcinoma (AdCC) of the breast masquerading as a large cystic-solid renal mass.
BMJ Case Rep
January 2025
Department of Urology, Austin Hospital, East Melbourne, Victoria, Australia.
Adenoid cystic carcinoma (AdCC) of the breast is a rare histological subtype of breast cancer, which usually has a low propensity for metastasis and is associated with a good prognosis. AdCC metastasis to the kidney is rare, with only 29 cases reported in the literature. We report a case of a woman in her 60s with multiple right-sided large cystic-solid renal lesions after a recent diagnosis of marginal zone B-cell lymphoma.
View Article and Find Full Text PDFAdenoid cystic carcinoma of the breast, from diagnosis to management: a case report.
J Med Case Rep
January 2025
Department of Pathology and Laboratories, University Hospital Fundación Santa Fe de Bogotá, Bogotá, DC, Colombia.
Background: Adenoid cystic carcinoma of the breast is a rare subtype, constituting less than 3.5% of primary breast carcinomas. Despite being categorized as a type of triple-negative breast cancer, it generally has a favorable prognosis.
View Article and Find Full Text PDFMULTIPLE MUSHROOM-LIKE GROWING CYLINDROMAS OF THE SCALP (TURBAN TUMOR) IN A PATIENT WITH BROOKE-SPIEGLER SYNDROME: UNIQUE MANIFESTATION IN A BULGARIAN PATIENT.
Georgian Med News
October 2024
1Onkoderma - Clinic for Dermatology, Venereology and Dermatologic Surgery, Sofia, Bulgaria.
Cutaneous cylindromas are rare, slow-growing adnexal tumors commonly found on the capillitium or face. When located on the capillitium, they can cluster together, forming a headgear-like structure that gives the characteristic "turban" appearance. Brooke-Spiegler syndrome, an autosomal dominant condition, is typically benign, though malignant transformation can occur.
View Article and Find Full Text PDFPersonalized Immunotherapy Achieves Complete Response in Metastatic Adenoid Cystic Carcinoma Despite Lack of Conventional Biomarkers.
Curr Oncol
September 2024
Medicana Health Group, Precision Oncology Center, 34750 Istanbul, Türkiye.
Article Synopsis
- * Genomic profiling of ACC shows low tumor mutational burden, a lack of actionable targets, and negative PD-L1, leading to recommendations for a specific combination of anti-PD-1 and anti-CTLA-4 immunotherapy.
- * A successful complete response was noted in a patient with treatment-resistant locally recurrent lacrimal gland ACC through personalized immunotherapy combined with other therapeutic strategies, highlighting the importance of considering patient-specific factors in immune-cold cancers.
Familiar cylindromatosis in a Colombian family caused by a mutation in CYLD.
Ecancermedicalscience
September 2024
Department of Human Genetics, Fundación Valle del Lili, Cali 760026, Colombia.
Article Synopsis
- The CYLD cutaneous syndrome leads to multiple skin tumors like cylindromas and spiradenomas, primarily affecting the face and head, with more frequent occurrence in women.
- A Colombian family spanning three generations showcased early onset of this syndrome, confirmed by genetic analysis identifying a specific variant in the CYLD gene.
- Understanding the genetic and environmental factors behind the syndrome is vital for developing better treatments and enhancing patient care.
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