Objective: To determine if there are measurable dynamic contact stress aberrations and kinematic abnormalities (instability) that have not been observed in conventional static loading studies of posterior malleolar ankle fractures.
Design: Cadaveric fracture model.
Setting: Biomechanics laboratory.
Intervention: Seven fresh cadaveric specimens were fixed in an unconstrained testing apparatus and loaded to one body weight. The ankle was moved from 25 degrees of plantarflexion to 15 degrees of dorsiflexion. The model included the intact ankle and four fracture simulations (50% fracture without internal fixation, 2 mm gap and step malreductions, and anatomically fixed).
Main Outcome Measure: Motion at the ankle was monitored with an electromagnetic tracking device, and intra-articular contact stresses were measured using a real-time stress sensor.
Results: There were no kinematic abnormalities suggestive of tibiotalar subluxation in any of the fracture simulations. There was no increase in peak contact stress in any of the fracture models compared with the unfractured model. However, there was a shift in the location of the contact stresses to a more anterior and medial location following the fracture. When summed over the range of motion, these areas of cartilage bore significantly higher cumulative contact stresses relative to the nonfracture situation.
Conclusions: We found no talar subluxation and no increase in contact stresses near the articular incongruity, making it unlikely that these factors explain the increased incidence of arthrosis after trimalleolar fractures (OTA/AO classification 44 B3 fractures). Rather, we found that the joint remaining bears increased stress and that the center of stress shifts anteriorly, loading cartilage that normally sees little load.
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http://dx.doi.org/10.1097/00005131-200405000-00002 | DOI Listing |
Sci Rep
January 2025
College of Landscape Architecture, Sichuan Agricultural University, Chengdu, 611130, China.
Ethylene is a signalling factor that plays a key role in the response of plants to abiotic stresses, such as cold stress. Recent studies have shown that the exogenous application of 1-aminocyclopropane-1-carboxylate (ACC), an ethylene promoter, affects plant cold tolerance. The cold-responsive specific gene DREB plays a crucial role in enhancing cold tolerance in plants by activating several cold-responsive (COR) genes.
View Article and Find Full Text PDFJ Biol Chem
January 2025
Department of Chemistry and Biochemistry, Baylor University, Waco, Texas, 76798-7348, USA. Electronic address:
Coupling interactions between the alpha (α) subunit of the polymerase III core (α-Pol III core) and the tau (τ) subunit of the clamp loader complex (τ-CLC) are vital for efficient and rapid DNA replication in Escherichia coli (E. coli). Specific and targeted mutations in the C-terminal τ-interaction region of the Pol III α-subunit disrupted efficient coupled rolling circle DNA synthesis in vitro and caused significant genomic defects in CRISPR-Cas9 dnaE edited cell strains.
View Article and Find Full Text PDFClin Biomech (Bristol)
January 2025
Ohio State University Wexner Medical Center, Department of Orthopaedics, Columbus, OH, USA. Electronic address:
Background: Low back pain affects over 80 % of adults, with sacroiliac joint dysfunction accounting for 15-30 % of these cases. Sacroiliac fusion is a surgical procedure for refractory joint pain. While the biomechanics of the joint and its fusion relative to the spinal column are well-known, the hip-spine relationship post-fusion remains unclear.
View Article and Find Full Text PDFSensors (Basel)
January 2025
Key Laboratory of Testing Technology for Manufacturing Process MOE, Southwest University of Science and Technology, Mianyang 621010, China.
The directivity of the quasi-static component (QSC) is quantitatively investigated for evaluating the orientation of a micro-crack buried in a thin solid plate using the numerical simulation method. Based on the bilinear stress-strain constitutive model, a three-dimensional (3D) finite element model (FEM) is built for investigating the nonlinear interaction between primary Lamb waves and the micro-crack. When the primary Lamb waves at A0 mode impinge on the micro-crack, under the modulation of the contact acoustic nonlinearity (CAN), the micro-crack itself will induce QSC.
View Article and Find Full Text PDFMaterials (Basel)
December 2024
International Joint Research Center on High-Value Utilization of Agricultural Waste Biomass Between Jiangsu University, China, and Mie University, Japan, Zhenjiang 212013, China.
Currently, wood-based panels are mainly made from wood and adhesives containing formaldehyde. With the growing demand for raw materials and increasing concern for human health, the use of residues from annual crops to manufacture binder-free biodegradable biomass boards has attracted increasing interest. The aim of this study was to develop a biodegradable bio-board without any adhesives using eggplant straw fibers.
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