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Unusual Cases of Monoclonal Gammopathy of Renal Significance.
Case Rep Nephrol
September 2024
Department of Pathology CIUSSS de la Mauricie-et-du-Centre-du-Québec, Trois-Rivières, Canada.
Article Synopsis
- Monoclonal gammopathy of renal significance (MGRS) is characterized by kidney issues linked to abnormal immunoglobulin production, found in patients without specific treatment criteria for hematological diseases.
- The three cases discussed include a patient with chronic lymphocytic leukemia and monoclonal membranoproliferative glomerulonephritis, a second patient with IgM MGUS presenting renal thrombotic microangiopathy, and a third with immunotactoid glomerulonephritis likely due to small B-cell lymphoma.
- Each case highlights unique renal complications tied to the presence of monoclonal proteins and emphasizes the challenges in diagnosis and management of MGRS in different
Diverse and atypical manifestations of Q fever in a metropolitan city hospital: Emerging role of next-generation sequencing for laboratory diagnosis of Coxiella burnetii.
PLoS Negl Trop Dis
April 2022
Department of Microbiology, Li Ka Shing Faculty of Medicine, The University of Hong Kong, Hong Kong, China.
Although Q fever has been widely reported in the rural areas of China, there is a paucity of data on the epidemiology and clinical characteristics of this disease in large metropolitan cities. In this study, we profile the epidemiology and clinical manifestations of Q fever from a tertiary hospital in Shenzhen, a Southern Chinese metropolitan city with a large immigrant population from other parts of China. A total of 14 patients were confirmed to have Q fever during a nine-year-and-six-month period, five of whom were retrospectively diagnosed during case review or incidentally picked up because of another research project on unexplained fever without localizing features.
View Article and Find Full Text PDFDelayed diagnosis of Angioimmunoblast T-cell lymphoma presenting with type II Cryoglobulinemia and acute kidney injury: a case report and narrative review of the literature.
BMC Nephrol
November 2020
Department of Nephrology, University of Hong Kong - Shenzhen Hospital, Shenzhen, China.
Background: Angioimmunoblastic T cell lymphoma (AITL) is an infrequent hematological malignancy with variable and often atypical presentations. The presence of dysproteinemia, autoantibodies and systemic involvement in AITL has often led to a delay in diagnosis or even misdiagnosis in practice. We herewith present a case of AITL that primarily presented with acute kidney injury associated with type II Cryoglobulinemia, the underlying cause was only identified 8 months after the emergence of initial symptoms.
View Article and Find Full Text PDFGlomerular endothelium in kidneys with congenital nephrotic syndrome of the Finnish type (NPHS1).
Nephrol Dial Transplant
April 2008
Hospital for Children and Adolescents, University of Helsinki, 00029 Helsinki, Finland.
Background: The role of glomerular capillary endothelium in the pathophysiology of nephrotic kidney diseases is poorly known. We analysed the glomerular endothelial lesions in kidneys from patients with congenital nephrotic syndrome of the Finnish type (NPHS1). The disorder is caused by a genetic defect in a major podocyte slit diaphragm protein, nephrin.
View Article and Find Full Text PDFCell cycle regulatory proteins in podocyte health and disease.
Nephron Exp Nephrol
July 2007
Division of Nephrology, University of Washington, Seattle, WA 98195, USA.
The glomerular visceral epithelial cell, or podocyte, is a highly specialized and terminally differentiated cell that is fundamental to the integrity of the glomerular filtration barrier and functions to prevent urinary protein leakage and to oppose intracapillary hydrostatic pressure. Common to many human kidney diseases and experimental animal models is a strong association between podocyte injury and the development of progressive kidney disease. Studies have shown that a decline in podocyte number strongly correlates with, and likely underlies, proteinuria and the progression to glomerulosclerosis.
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