The heat shock protein Hsp90 is essential for uptake of the binary actin ADP-ribosylating toxins Clostridium perfringens iota-toxin and Clostridium difficile transferase into eukaryotic cells. Inhibition of Hsp90 by its specific inhibitor radicicol delayed intoxication of Vero cells by these toxins. A common Hsp90-dependent mechanism for their translocation is discussed.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387881 | PMC |
| http://dx.doi.org/10.1128/IAI.72.5.3066-3068.2004 | DOI Listing |
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