We report the identification of two peptides from Salmonella OmpC porin that can bind to major histocompatibility complex class I K(b) molecules and are targets of cytotoxic T lymphocytes from Salmonella-infected mice. These peptides are conserved in gram-negative bacterial porins and are the first Salmonella porin-specific epitopes described for possible CD8(+)-T-cell elimination of infected cells.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC387851 | PMC |
| http://dx.doi.org/10.1128/IAI.72.5.3059-3062.2004 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
In silico designing and characterization of outer membrane protein (OmpC) gene from Salmonella enterica and its expression in Nicotiana tabacum for developing a plant-based vaccine against salmonellosis.
Microb Pathog
February 2025
Department of Biochemistry, Faculty of Biological Sciences, Quaid-i-Azam University, Islamabad, Pakistan. Electronic address:
Salmonella, a gram-negative bacteria, is the leading cause of foodborne illness globally. Two serovars of Salmonella, S. enteritidis and S.
View Article and Find Full Text PDFEvaluation of Multidrug Resistance of Isolated from Pork Meat Obtained from Traditional Slaughter Systems in Romania.
Microorganisms
October 2024
Department of Animal Husbandry and Public Health, Faculty of Veterinary Medicine Cluj-Napoca, University of Agricultural Sciences and Veterinary Medicine Cluj, 400372 Cluj-Napoca, Romania.
Article Synopsis
- * Out of 208 pork samples collected over four years, 23.07% tested positive for Salmonella, primarily the serovars Infantis, Typhimurium, and Derby, with high rates of multidrug resistance.
- * The research calls for improved surveillance and control measures in pork production to address antibiotic resistance and mitigate the risk of foodborne illnesses linked to contaminated meat.
Bioactive compounds from fermented leaf: Potent antibiotics against multidrug-resistant and .
In Silico Pharmacol
November 2024
Department of Biochemistry, Faculty of Basic Medical Sciences, Redeemer's University, Ede, Osun State Nigeria.
Unlabelled: Antibiotic resistance microorganisms (ARMs), particularly gram-negative bacteria, pose a global health threat. The effects of fermentation on phytochemicals are numerous, and exploring this potential is the focus of drug development. The study investigated the role of fermentation in modifying leaf secondary metabolites as an effective antibiotic against .
View Article and Find Full Text PDFExploration of Klebsiella aerogenes derived secondary metabolites and their antibacterial activities against multidrug-resistant bacteria.
PLoS One
September 2024
Department of Pathology, Ditmanson Medical Foundation, Chia-Yi Christian Hospital, Chiayi, Taiwan.
Article Synopsis
- The study focuses on the need for new treatment strategies against antimicrobial resistance, specifically by exploring endophytic bacteria from medicinal plants as sources of novel antibiotics.
- Klebsiella aerogenes was isolated from the plant Kalanchoe blossfeldiana and analyzed for its secondary metabolites using GC-MS, resulting in the identification of 36 compounds.
- The ethyl acetate extract of K. aerogenes showed significant antibacterial activity against multi-drug resistant Salmonella typhi and moderate efficacy against Staphylococcus aureus, indicating its potential for future drug development.
Stress response of Newport with various sequence types toward plasma-activated water: Viable but nonculturable state formation and outer membrane vesicle production.
Curr Res Food Sci
May 2024
Department of Food Science and Nutrition, College of Biosystems Engineering and Food Science, Zhejiang University, Hangzhou, 310058, China.
This study aims to investigate the response of Newport to plasma-activated water (PAW), a novel disinfectant that attracts attention due to its broad-spectrum antimicrobial efficacy and eco-friendliness. In this work, we demonstrated that . Newport of different sequence types (STs) could be induced into the viable but nonculturable (VBNC) state by PAW treatment.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!