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Levetiracetam for pediatric migraine prophylaxis: A narrative review.
Brain Dev
November 2024
Student Research Committee Jiroft University of Medical Sciences, Jiroft, Iran; Bio Environmental Health Hazards Research Center, Jiroft University of Medical Sciences, Jiroft, Iran. Electronic address:
Background: Migraine, a common primary headache disorder, affects children and adolescents under 18, often bilateral and lasting 2-72 hours, affecting 7.7% of them.
Objective: Recent studies on migraine prevention and treatment in children and adolescents have explored the potential benefits of levetiracetam, considering its side effects and potential effects on migraines.
Anti-epileptic Drugs Use and Increased Risk of Stroke: A Systematic Review.
Ann Neurosci
January 2024
Maharajgunj Medical Campus, Tribhuvan University, Institute of Medicine, Maharajgunj, Kathmandu, Nepal.
Antiepileptic drugs (AEDs), the predominant treatment for epilepsy, are also utilised for migraine, neuropathic pain, and bipolar disorders, accounting for 1% of usage among the common population. There is a greater risk of stroke, heart attack, and arrhythmia among AED users particularly those with enzyme-inducing properties. This systematic review aimed to look into the ischemic stroke risk among AED users, particularly in patients who had never had a cerebrovascular accident before.
View Article and Find Full Text PDFUpdated Canadian Headache Society Migraine Prevention Guideline with Systematic Review and Meta-analysis.
Can J Neurol Sci
November 2024
Ottawa Hospital, Division of Neurology, University of Ottawa, Ottawa, ON, Canada.
Objective: We have updated the migraine prevention guideline of the Canadian Headache Society from 2012, as there are new therapies available, and additionally, we have provided guidelines for the prevention of chronic migraine, which was not addressed in the previous iteration.
Methods: We undertook a systematic review to identify new studies since the last guideline. For studies identified, we performed data extraction and subsequent meta-analyses where possible.
Preventive Medications in Pediatric Migraine: A Network Meta-Analysis.
JAMA Netw Open
October 2024
The George Institute for Global Health, University of New South Wales, Sydney, Australia.
Article Synopsis
- Pediatric migraines negatively affect kids' daily lives and school performance, making it essential to find effective treatments for prevention.
- A network meta-analysis was conducted to compare the efficacy and safety of different oral medications for stopping migraine episodes in children.
- The study aimed to analyze data from various clinical trials to determine how well these treatments work and identify any potential side effects.
Novel Mitochondrial Cytopathy Causing Mitochondrial Encephalomyopathy With Lactic Acidosis and Stroke-Like Episodes Syndrome and Tubulointerstitial Nephropathy.
Cureus
August 2024
Internal Medicine, Stockport National Health Service (NHS) Trust, Stockport, GBR.
Article Synopsis
- Mitochondrial cytopathies, particularly from MT-TL1 and MT-ND5 mutations, can lead to mitochondrial encephalomyopathy with lactic acidosis and stroke-like episodes (MELAS), marked by multi-organ dysfunction, with a novel MT-ND5 variant being only the second reported case linked to MELAS.
- A middle-aged man presented with severe neurological symptoms, including confusion, speech difficulties, and behavioral changes, alongside a history of refractory seizures and renal disease; imaging revealed significant brain abnormalities, and muscle biopsy identified a novel mutation in the MT-ND5 gene.
- MELAS typically features seizures, stroke-like episodes, and other neurological issues, with kidney transplants in these patients generally offering
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