AI Article Synopsis
- The study aimed to identify the different types of Hepatitis B virus (HBV) DNA and their genotypes in patients.
- The researchers used Polymerase Chain Reaction and Nucleic Acid hybridization to analyze samples, finding that a significant portion of patients had genotype B.
- Results showed genotype B had higher ALT levels and HBe positivity compared to genotype C, with no clear links between genotypes and patient demographics like age or sex.
Article Abstract
Objective: To detect HBV DNA and its genotypes.
Methods: The 6 isoforms of HBV DNA was detected out using of different probes by Polymerase Chain Reaction and Nucleic Acid hybridization.
Results: Of 150 HBV DNA positive patients who lived in Shenzhen, 50 samples (33%) are type B, 36 samples (24%) are type C, 13 samples (9%) are type D, 3 samples is type F, 1 sample is type A, 48 samples (31%) are mixed type. The ALT value was significantly higher in genotype B than in genotype C. HBe positivity were higher in genotype B than genotype C. HBeAg positivity were higher in genotype C than in genotype B. There are not obvious relations between genotype and age or sex.
Conclusion: In the detected samples, the major genotype of HBV DNA is type B, several are type C, D. The type E haven't been found. There are some relations between all kinds of genotypes and the severity of hepatitis B.
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